COL8A1 Protein (His tag)

N° du produit ABIN7318323

Détail du produit

Antigène: COL8A1 (Collagen, Type VIII, alpha 1 (COL8A1))

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette COL8A1 protéine est marqué à la His tag.

Fonction: Recombinant Human COL8A1 Protein (His Tag)

Séquence: Gly28-Met744

Attributs du produit: Recombinant Human Collagen alpha-1(VIII) Chain is produced by our Mammalian expression system and the target gene encoding Gly28-Met744 is expressed with a 6His tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM Tris,150 mM NaCl, pH 8.0.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: COL8A1 (Collagen, Type VIII, alpha 1 (COL8A1))

Autre désignation: COL8A1 (COL8A1 Produits)

Synonymes: COL8A1 Protein, Col8a-1 Protein, C3orf7 Protein, collagen type VIII alpha 1 chain Protein, collagen, type VIII, alpha 1 S homeolog Protein, collagen, type VIII, alpha 1 Protein, COL8A1 Protein, col8a1.S Protein, Col8a1 Protein

Sujet:

Background: Collagen alpha-1(VIII) chain, also known as endothelial collagen, C3orf7 and COL8A1, can be cleaved into vastatin chain. COL8A1 is a short chain collagen and a major component of the basement membrane of the corneal endothelium. COL8A1 forms homotrimers, or heterotrimers in association with alpha 2(VIII) type collagens. Four homotrimers can form a tetrhedron stabilized by central interacting C-terminal NC1 trimers. COL8A1 contains one C1q domain and is primarily expressed in the subendothelium of large blood vessels. The expression level can be up-regulated during vascular injury, in atherosclerosis and in diabetes. COL8A1 may have a role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis.

Synonym: Collagen Alpha-1(VIII) Chain, Endothelial Collagen, Vastatin, COL8A1, C3orf7

Poids moléculaire: 71.6 kDa

UniProt: P27658