C1QB Protein (His tag)

N° du produit ABIN7317714

Détail du produit

Antigène: C1QB (Complement Component 1, Q Subcomponent, B Chain (C1QB))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette C1QB protéine est marqué à la His tag.

Fonction: Recombinant Human C1QB/C1qB Protein (His Tag)

Séquence: Met 1-Ala 253

Attributs du produit: A DNA sequence encoding the human C1QB (NP_000482.3) precursor (Met 1-Ala 253) was expressed, with a carboxy-terminal polyhistidine tag.

Pureté: > 94 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 50 mM Tris, 100 mM NaCl, 0.5 mM TCEP, 10 % glycerol, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: C1QB (Complement Component 1, Q Subcomponent, B Chain (C1QB))

Autre désignation: C1QB/C1qB (C1QB Produits)

Synonymes: complement C1q B chain Protein, complement component 1, q subcomponent, beta polypeptide Protein, C1QB Protein, C1qb Protein

Sujet:

Background: Complement Component 1, q subcomponent (C1q) associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Southern blot analysis of chromosomal DNA from vertebrate species demonstrated highest similarity between the C1qB genes, followed by C1qC and finally C1qA. Sequence comparison of C1q from three different species have shown that the B chains have the strongest similarity. C1q was already present at embryonic day 14 (E14) and showed little change in abundance through six weeks postnatal. At E16, C1qB mRNA was present at high abundance in putative microglia/macrophages in cortical marginal and intermediate zones, and hippocampal analge.

Synonym: C1QB

Poids moléculaire: 25 kDa

NCBI Accession: NP_000482

Pathways: Système du Complément