CDK2AP2 Protein (His tag)

N° du produit ABIN7317362

Détail du produit

Antigène: CDK2AP2 (Cyclin-Dependent Kinase 2 Associated Protein 2 (CDK2AP2))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette CDK2AP2 protéine est marqué à la His tag.

Fonction: Recombinant Human CDK2AP2 Protein (E.coli, His Tag)

Séquence: Met 1-Thr 126

Attributs du produit: A DNA sequence encoding the human CDK2AP2 (O75956) (Met 1-Thr 126) was fused with a polyhistidine tag at the C-terminus.

Pureté: > 78 %(the upper band)+17 %(the lower band) as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, 15 % glycerol, pH 7.5

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: CDK2AP2 (Cyclin-Dependent Kinase 2 Associated Protein 2 (CDK2AP2))

Autre désignation: CDK2AP2 (CDK2AP2 Produits)

Synonymes: DOC-1R Protein, p14 Protein, zgc:92182 Protein, 5830466O21Rik Protein, D19Ertd144e Protein, Doc-1r Protein, cyclin dependent kinase 2 associated protein 2 Protein, cyclin-dependent kinase 2 associated protein 2 Protein, CDK2-associated protein 2 Protein, CDK2AP2 Protein, cdk2ap2 Protein, Cdk2ap2 Protein

Sujet:

Background: CDK2AP2 belongs to the CDK2AP family. Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. CDK2AP2 contains 5 distinct gt-ag introns. Transcription produces 7 different mRNAs, 6 alternatively spliced variants and 1 unspliced form. There are 2 non overlapping alternative last exons and 4 validated alternative polyadenylation sites. The mRNAs appear to differ splicing versus retention of 3 introns. CDK2AP2 plays a role in regulating self-renewal of mouse embryonic stem cells (mESC) under permissive conditions, and cell survival during differentiation of the mESC into terminally differentiated cell types.

Synonym: Cyclin-dependent kinase 2-associated protein 2,CDK2-associated protein 2,DOC-1-related protein,DOC-1R,CDK2AP2,DOC1R,p14

Poids moléculaire: 14.5 kDa

UniProt: O75956

Pathways: Signalisation PI3K-Akt, Cycle Cellulaire, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA