EPH Receptor A4 Protein (EPHA4) (AA 570-986) (GST tag,His tag)

N° du produit ABIN7317076

Détail du produit

Antigène: EPH Receptor A4 (EPHA4)

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 570-986

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette EPH Receptor A4 protéine est marqué à la GST tag,His tag.

Fonction: Recombinant Human EphA4 Protein (aa 570-986, His &GST Tag)(Active)

Séquence: Ser 570-Val 986

Attributs du produit: A DNA sequence encoding the human EPHA4 (P54764) (Ser570-Val986) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Pureté: > 99 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: 1. The specific activity was determined to be 17 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate.2. Measured by its binding ability in a functional ELISA. Immobilized human EPHA4 (aa 570-986)at 10 μg/ml (100 μl/well) can bind biotinylated human EphrinA5-His with a linear range of 0.625-5.0 μg/ml.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 8.5, 10 % glycerol, 3 mM DTT

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: EPH Receptor A4 (EPHA4)

Autre désignation: EphA4 (EPHA4 Produits)

Synonymes: HEK8 Protein, SEK Protein, TYRO1 Protein, RGD1560587 Protein, ephe Protein, EPHA4 Protein, Ci-Eph1 Protein, sek Protein, hek8 Protein, rtk1 Protein, tyr01 Protein, 2900005C20Rik Protein, AI385584 Protein, Cek8 Protein, Hek8 Protein, Sek Protein, Sek1 Protein, Tyro1 Protein, rb Protein, XEpha4 Protein, sek-1 Protein, epha4 Protein, pag Protein, EphA4 Protein, apha3 Protein, ek2 Protein, epha3 Protein, sb:cb246 Protein, zek2 Protein, zgc:109882 Protein, EPH receptor A4 Protein, Eph receptor A4 Protein, ephrin receptor epsilon Protein, EPH receptor A4 S homeolog Protein, EPH receptor A4 L homeolog Protein, eph receptor A4a Protein, EPHA4 Protein, Epha4 Protein, ephe Protein, epha4 Protein, epha4.S Protein, epha4.L Protein, epha4a Protein

Sujet:

Background: EPH receptor A4 (ephrin type-A receptor 4); also known as EphA4; belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1; EPHA2; EPHA3; EPHA4; EPHA5; EPHA6; EPHA7; EPHA8; EPHA9; EPHA10; EPHB1; EPHB2; EPHB3; EPHB4; EPHB5; EPHB6. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. EphA4 is enriched on dendritic spines of pyramidal neurons in the adult mouse hippocampus; and ephrin-A3 is localized on astrocytic processes that envelop spines. Eph receptor−mediated signaling; which is triggered by ephrins7; probably modifies the properties of synapses during synaptic activation and remodeling. Ephrin receptors are components of cell signalling pathways involved in animal growth and development; forming the largest sub-family of receptor tyrosine kinases (RTKs). The extracellular domain of an EphA4 interacts with ephrin ligands; which may be tethered to neighbouring cells. Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer.

Synonym: Ephrin type-A receptor 4;HEK8; SEK; TYRO1;EPHA4;Tyrosine-protein kinase receptor SEK;Tyrosine-protein kinase TYRO1;EK8;hEK8;EPH-like kinase 8

Poids moléculaire: 75 kDa

UniProt: P54764

Pathways: Signalisation RTK