EPH Receptor B6 Protein (EPHB6) (His tag)
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- Antigène Voir toutes EPH Receptor B6 (EPHB6) Protéines
- EPH Receptor B6 (EPHB6)
- Type de proteíne
- Recombinant
- Activité biologique
- Active
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette EPH Receptor B6 protéine est marqué à la His tag.
- Fonction
- Recombinant Human EphB6 Protein (His Tag)(Active)
- Séquence
- Met 1-Ser 579
- Attributs du produit
- The extracellular domain (Met 1-Ser 579) of human EphB6 (NP_004436.1) precursor was expressed, fused with a polyhistidine tag at the C-terminus.
- Pureté
- > 92 % as determined by reducing SDS-PAGE.
- niveau d'endotoxine
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- 1. Measured by its binding ability in a functional ELISA.2. Immobilized recombinant human EphB6 at 10 μg/ml (100 μl/well) can bind human EphrinB1 with a linear range of 32-800 ng/ml.3. Immobilized recombinant human EphB6 at 10 μg/ml (100 μl/well) can bind human EphrinB2 with a linear range of 1.28-32 ng/ml.
- Top Product
- Discover our top product EPHB6 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Antigène
- EPH Receptor B6 (EPHB6)
- Autre désignation
- EphB6 (EPHB6 Produits)
- Synonymes
- CEK9 Protein, EPHB5 Protein, Cekl Protein, Mep Protein, HEP Protein, EPH receptor B6 Protein, Eph receptor B6 Protein, EPHB6 Protein, Ephb6 Protein
- Sujet
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Background: Ephrins are divided into the ephrin-A (EFNA) class and the ephrin-B (EFNB) class based on their structures and sequence relationships. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB6 is an unusual Eph receptor, lacking catalytic capacity due to alterations in its kinase domain. Interestingly, increased metastatic activity is associated with reduced EphB6 receptor expression in several tumor types, including breast cancer. This emphasizes the potential of EphB6 to act as a suppressor of cancer aggressiveness. EphB6 suppress cancer invasiveness through c-Cbl-dependent signaling, morphologic changes, and cell attachment and indicate that EphB6 may represent a useful prognostic marker and a promising target for therapeutic approaches. EphB6 can both positively and negatively regulate cell adhesion and migration, and suggest that tyrosine phosphorylation of the receptor by an Src family kinase acts as the molecular switch for the functional transition. In addition, Ephrin-B2 may be a physiological ligand for the EphB6 receptor.
Synonym: HEP
- Poids moléculaire
- 61.6 kDa
- NCBI Accession
- NP_004436
- Pathways
- Signalisation RTK, Hormone Transport
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