Ephrin B1 Protein (EFNB1) (His tag,Fc Tag)

N° du produit ABIN7317730

Détail du produit

Antigène: Ephrin B1 (EFNB1)

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette Ephrin B1 protéine est marqué à la His tag,Fc Tag.

Fonction: Recombinant Human Ephrin-B1/EFNB1 Protein (His & Fc Tag)(Active)

Séquence: Met 1-Gly 232

Attributs du produit: A DNA sequence encoding the human EFNB1 (NP_004420.1) extracellular domain (Met 1-Gly 232) was was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.

Pureté: >(79.7+18.0) % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Measured by its binding ability in a functional ELISA. Immobilized mouse EphB3 at 2 μg/ml (100 μl/well) can bind human EFNB1 Fc chimera with a linear ranger of 1.56-25 ng/ml.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: Ephrin B1 (EFNB1)

Autre désignation: Ephrin-B1/EFNB1 (EFNB1 Produits)

Synonymes: EFNB1 Protein, LERK2 Protein, Cek5-L Protein, EFL-3 Protein, Elk-L Protein, Epl2 Protein, Eplg2 Protein, LERK-2 Protein, Lerk2 Protein, Stra1 Protein, CFND Protein, CFNS Protein, EFL3 Protein, EPLG2 Protein, cfnd Protein, cfns Protein, efl3 Protein, efnb1-A Protein, ephrinB1 Protein, eplg2 Protein, lerk2 Protein, ephrin B1 Protein, ephrin-B1 Protein, ephrin-B1 L homeolog Protein, EFNB1 Protein, Efnb1 Protein, efnb1 Protein, efnb1.L Protein

Sujet:

Background: Ephrin-B1 also known as EFNB1, is a member of the ephrin family. The transmembrane- associated ephrin ligands and their Eph family of receptor tyrosine kinases are expressed by cells of the SVZ. Eph/ephrin interactions are implicated in axon guidance, neural crest cell migration, establishment of segmental boundaries, and formation of angiogenic capillary plexi. Eph receptors and ephrins are divided into two subclasses, A and B, based on binding specificities. Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. An exception is the EphA4 receptor, which binds both subclasses of ephrins. EphrinB1 and B class Eph receptors provide positional cues required for the normal morphogenesis of skeletal elements. Another malformation, preaxial polydactyly, was exclusively seen in heterozygous females in which expression of the X-linked ephrinB1 gene was mosaic, so that ectopic EphB-ephrinB1 interactions led to restricted cell movements and the bifurcation of digital rays.

Synonym: Ephrin-B1,EFL-3, ELK ligand, EPH-related receptor tyrosine kinase ligand 2,LERK-2,CFND,CFNS,EFB1,EFL3,Elk-L,EPLG2,LERK2

Poids moléculaire: 51.2 kDa

NCBI Accession: NP_004420

Pathways: Signalisation RTK