GFRA3 Protein (Fc Tag)

N° du produit ABIN7320117

Détail du produit

Antigène: GFRA3 (GDNF Family Receptor alpha 3 (GFRA3))

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette GFRA3 protéine est marqué à la Fc Tag.

Fonction: Recombinant Mouse GFRA3/GFR-alpha-3 Protein (Fc Tag)

Séquence: Met 1-Arg 379

Attributs du produit: A DNA sequence encoding the mouse GFRA3 (O35118) (Met 1-Arg 379), was fused with the Fc region of human IgG1 at the C-terminus.

Pureté: > 80 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: GFRA3 (GDNF Family Receptor alpha 3 (GFRA3))

Autre désignation: GFRA3/GFR-alpha-3 (GFRA3 Produits)

Synonymes: GFRA3 Protein, GFRalpha3 Protein, Y15110 Protein, GDNF family receptor alpha 3 Protein, glial cell line derived neurotrophic factor family receptor alpha 3 Protein, Gfra3 Protein, GFRA3 Protein

Sujet:

Background: Glial cell line derived neurotrophic factor (GDNF) Family Receptor Alpha 3 (GFRA3) or GDNFRa3 is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. GFRA3 / GDNFRa3 is a potent survival factor for central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are its binding ligand which are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF promotes the formation of a physical complex between GFRA/GDNFRa and the orphan tyrosin kinase receptor Ret, thereby inducing its tyrosine phosphorylation. The RET is a receptor tyrosine kinase representing the signal-transducing molecule of a multisubunit surface receptor complex for the GDNF, in which GFRA / GDNFRa acts as the ligand-binding component. The neurotrophic growth factor artemin binds selectively to GDNF family receptor α3 (GFRA3 / GDNFRa3), forming a molecular complex with the co-receptor RET which mediates downstream signaling. This signaling pathway has been demonstrated to play an important role in the survival and maintenance of nociceptive sensory neurons and in the development of sympathetic neurons.

Synonym: GFRalpha3;Y15110

Poids moléculaire: 66.2 kDa

UniProt: O35118