GP1BB Protein (His tag)

N° du produit ABIN7317775

Détail du produit

Antigène: GP1BB (Glycoprotein Ib (Platelet), beta Polypeptide (GP1BB))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette GP1BB protéine est marqué à la His tag.

Fonction: Recombinant Human GP1BB/CD42c Protein (His Tag)

Séquence: Met 1-Cys 147

Attributs du produit: A DNA sequence encoding the human GPIb, β polypeptide extracellular domain (NP_000398.1) (Met 1-Cys 147) with a C-terminal polyhistidine tag was expressed.

Pureté: > 97 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: GP1BB (Glycoprotein Ib (Platelet), beta Polypeptide (GP1BB))

Autre désignation: GP1BB/CD42c (GP1BB Produits)

Synonymes: BDPLT1 Protein, BS Protein, CD42C Protein, GPIBB Protein, glycoprotein Ib (platelet), beta polypeptide Protein, glycoprotein Ib platelet beta subunit Protein, glycoprotein Ib, beta polypeptide Protein, GP1BB Protein, Gp1bb Protein

Sujet:

Background: Platelet glycoprotein Ib (GPIb) complex is best known as a major platelet receptor for von Willebrand factor essential for platelet adhesion under high shear conditions found in arteries and in thrombosis. The GPIb complex is composed of GPIb alpha (Platelet glycoprotein Ib alpha chain) covalently attached to GPIb beta (Platelet glycoprotein Ib beta chain) and noncovalently complexed with GPIX and GPV. GPIb-beta, also known as GP1BB, CD42b-beta and CD42c, is single-pass type I membrane protein expressed in heart and brain, which is a critical component of the von Willebrand factor (vWF) receptor. The cysteine knot region of GPIb beta in the N terminus is critical for the conformation of GPIb beta that interacts with GPIX. The precursor of GP1BB is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. GPIb is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. GPIb alpha chain provides the vWF binding site, and GPIb beta chain contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. GP1BB is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (vWF), and mediates platelet adhesion in the arterial circulation. Defects in GP1BB are a cause of Bernard-Soulier syndrome (BSS), also known as giant platelet disease (GPD). BSS patients have unusually large platelets and have a clinical bleeding tendency.

Synonym: BDPLT1,BS,CD42C,GPIBB

Poids moléculaire: 14.3 kDa

NCBI Accession: NP_000398