GM2A Protein (His tag)

N° du produit ABIN7195977

Détail du produit

Antigène: GM2A (GM2 Ganglioside Activator (GM2A))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette GM2A protéine est marqué à la His tag.

Fonction: Recombinant Human GM2A Protein (Baculovirus, His Tag)

Séquence: Met 1-Ile 193

Attributs du produit: A DNA sequence encoding the human GM2A (AAA35907.1) (Met 1-Ile 193) was fused with a polyhistidine tag at the C-terminus.

Pureté: > 96 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: GM2A (GM2 Ganglioside Activator (GM2A))

Autre désignation: GM2A (GM2A Produits)

Synonymes: GM2A Protein, fb96e04 Protein, fb96e10 Protein, wu:fb96e04 Protein, wu:fb96e10 Protein, zgc:110188 Protein, MGC84154 Protein, GM2-AP Protein, SAP-3 Protein, AA408702 Protein, AW215435 Protein, GM2 ganglioside activator Protein, GM2 ganglioside activator L homeolog Protein, GM2 ganglioside activator protein Protein, Gm2a Protein, GM2A Protein, gm2a Protein, gm2a.L Protein

Sujet:

Background: GM2A (GM2 ganglioside activator), is a lipid transfer protein which belongs to the ML domain family. GM2A can accommodate several single chain phospholipids and fatty acids. It also exhibits some calcium-independent phospholipase activity. GM2A binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. GM2A acts as a substrate specific co-factor for the lysosomal enzyme β-hexosaminidase A. β-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. Defects in GM2A are the cause of GM2-gangliosidosis type AB (GM2GAB), also known as Tay-Sachs disease AB variant.

Synonym: Ganglioside GM2 activator;Cerebroside sulfate activator protein;GM2-AP;Sphingolipid activator protein 3;SAP-3

Poids moléculaire: 19.8 kDa