GFER Protein (His tag)

N° du produit ABIN7318458

Détail du produit

Antigène: GFER (Growth Factor, Augmenter of Liver Regeneration (GFER))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette GFER protéine est marqué à la His tag.

Fonction: Recombinant Human GFER Protein (His Tag)

Séquence: Met 1-Asp125

Attributs du produit: Recombinant Human Growth Factor, Augmenter of Liver Regeneration is produced by our E.coli expression system and the target gene encoding Met1-Asp125 is expressed with a 6His tag at the N-terminus.

Pureté: > 90 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: GFER (Growth Factor, Augmenter of Liver Regeneration (GFER))

Autre désignation: GFER (GFER Produits)

Synonymes: ALR Protein, ERV1 Protein, HERV1 Protein, HPO Protein, HPO1 Protein, HPO2 Protein, HSS Protein, Alr Protein, growth factor, augmenter of liver regeneration Protein, growth factor, augmenter of liver regeneration L homeolog Protein, GFER Protein, Gfer Protein, gfer.L Protein

Sujet:

Background: GFER is a hepatotrophic growth factor and flavin-linked sulfhydryl oxidase which belongs to the Erv1/ALR family of proteins. GFER is widely expressed in various human tissues. They are two isoforms of this protein. Isoform 1 could regenerate the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. Isoform 2 may act as an autocrine hepatotrophic growth factor promoting liver regeneration. GFER could also induce the expression of S-adenosylmethionine decarboxyl-ase and ornithine decarboxylases (ODC). S-adenosylmethionine decarboxyl-ase and ornithine decarboxylases play an important role in the synthesis of polyamines.

Synonym: FAD-linked sulfhydryl oxidase ALR,GFER,Augmenter of liver regeneration,hERV1,Hepatopoietin,GFER,ALR,HERV1,HPO

Poids moléculaire: 17.3 kDa

UniProt: P55789

Pathways: SARS-CoV-2 Protein Interactome