HRSP12 Protein (His tag)

N° du produit ABIN7318565

Détail du produit

Antigène: HRSP12 (Heat-Responsive Protein 12 (HRSP12))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette HRSP12 protéine est marqué à la His tag.

Fonction: Recombinant Human RIDA/HRSP12 Protein (His Tag)

Séquence: Met 1-Leu137

Attributs du produit: Recombinant Human Heat-Responsive Protein 12 is produced by our E.coli expression system and the target gene encoding Met1-Leu137 is expressed with a 6His tag at the N-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 100 mM NaCl, 1 mM DTT, 10 % Glycerol, pH 8.0.

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: HRSP12 (Heat-Responsive Protein 12 (HRSP12))

Autre désignation: RIDA/HRSP12 (HRSP12 Produits)

Synonymes: P14.5 Protein, PSP Protein, UK114 Protein, HR12 Protein, HRP12 Protein, PSP1 Protein, Psp Protein, HRSP12 Protein, zgc:101025 Protein, zgc:92739 Protein, reactive intermediate imine deaminase A homolog Protein, ribonuclease UK114 Protein, heat-responsive protein 12 Protein, ribonuclease UK114 pseudogene Protein, RIDA Protein, Rida Protein, LOC698724 Protein, LOC711809 Protein, NGR_b07070 Protein, LOC100353046 Protein, hrsp12 Protein

Sujet:

Background: Heat-Responsive Protein 12 (HRSP12) is an endoribonuclease that belongs to the Rut family. HRSP12 is found mainly in the human adult kidney and liver and is responsible for inhibiting protein translation by cleaving mRNA. HRSP12 only cleaves phosphodiester bonds in single-stranded RNA and inhibits cell-free protein synthesis. The levels of both mRNA and protein are markedly reduced in heptatocellular tumors and in human hepatoma cell lines compared with normal liver tissues. Moreover the levels of HRSP12 are different depending on the grade of the tumor. This had led to the suggestion that HRSP12 may be an important biomarker for heptatic carcinoma.

Synonym: Ribonuclease UK114, 14.5 kDa Translational Inhibitor Protein, p14.5, Heat-Responsive Protein 12, UK114 Antigen Homolog, HRSP12, PSP

Poids moléculaire: 16.7 kDa

UniProt: P52758