HEPACAM Protein (His tag)

N° du produit ABIN7318573

Détail du produit

Antigène: HEPACAM (Hepatic and Glial Cell Adhesion Molecule (HEPACAM))

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette HEPACAM protéine est marqué à la His tag.

Fonction: Recombinant Human HEPACAM Protein (His Tag)

Séquence: Val34-Ser240

Attributs du produit: Recombinant Human Hepatocyte Cell Adhesion Molecule is produced by our Mammalian expression system and the target gene encoding Val34-Ser240 is expressed with a 6His tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: HEPACAM (Hepatic and Glial Cell Adhesion Molecule (HEPACAM))

Autre désignation: HEPACAM (HEPACAM Produits)

Synonymes: GlialCAM Protein, MLC2A Protein, MLC2B Protein, 2900042E01Rik Protein, Hepn1 Protein, hepatic and glial cell adhesion molecule Protein, hepatocyte cell adhesion molecule Protein, HEPACAM Protein, Hepacam Protein

Sujet:

Background: Hepatocyte Cell Adhesion Molecule (HEPACAM) is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. HEPACAM includes a signal sequence (amino acid 1-33), an extracellular region (amino acid 34-240) with one Ig-like C2-type domain and one Ig-like V-type domain, a transmembrane segment (amino acid 241-261), and a cytoplasmic domain (amino acid 262 - 416). The cytoplasmic domain plays an important role in regulation of cell-matrix adhesion and cell motility. HEPACAM acts as a homodimer and dimer formation occurs predominantly through cis interactions on the cell surface. HEPACAM is involved in cell motility and cell-matrix interactions. The expression of this gene is down-regulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene.

Synonym: Hepatocyte Cell Adhesion Molecule, Protein HepaCAM, HEPACAM

Poids moléculaire: 24.1 kDa

UniProt: Q14CZ8