IGFBP6 Protein (His tag)
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- Antigène Voir toutes IGFBP6 Protéines
- IGFBP6 (Insulin-Like Growth Factor Binding Protein 6 (IGFBP6))
- Type de proteíne
- Recombinant
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Origine
- Souris
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Source
- Human Cells
- Purification/Conjugué
- Cette IGFBP6 protéine est marqué à la His tag.
- Fonction
- Recombinant Mouse IGFBP6/IGFBP-6 Protein (His Tag)
- Séquence
- Ala26-Gly238
- Attributs du produit
- Recombinant Mouse Insulin-Like Growth Factor-Binding Protein 6 is produced by our Mammalian expression system and the target gene encoding Ala26-Gly238 is expressed with a 6His tag at the C-terminus.
- Pureté
- > 95 % as determined by SDS-PAGE
- niveau d'endotoxine
- < 1.0 EU per μg as determined by the LAL method.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, EDTA,DTT, pH 7.4.
- Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Antigène
- IGFBP6 (Insulin-Like Growth Factor Binding Protein 6 (IGFBP6))
- Autre désignation
- IGFBP6/IGFBP-6 (IGFBP6 Produits)
- Synonymes
- IBP6 Protein, IGFBP-6 Protein, IGF-BP6 Protein, RBP6A Protein, IGFBP6 Protein, igfbp6 Protein, insulin like growth factor binding protein 6 Protein, insulin-like growth factor binding protein 6 Protein, IGFBP6 Protein, Igfbp6 Protein, IGFBP-6 Protein, igfbp6 Protein
- Sujet
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Background: Insulin-like growth factors (IGFs) comprise a family of endocrine, paracrine and autocrine polypeptides consisting of the ligands IGF1 and IGF2, two receptors (IGF1R, IGF2R), at least 6 IGF-binding proteins (IGFBPs) and IGFBP proteases. Among the binding proteins, IGFBP6 is unique because of its N-terminal disulfide linkages and its marked binding preference for IGF2. It is a potent inhibitor of the interaction between IGF2 and its receptor IGF1R, thus preventing major functions of IGF2, such as induction of proliferation, differentiation, cell adhesion, or colony formation. In particular, IGFBP-6 inhibited the growth of neuroblastoma and rhabdomyosarcoma xenografts. GFBP-6 is expressed in many tissues, including lung, liver, gut and the central nervous system.
Synonym: Insulin-like growth factor-binding protein 6, IBP-6, IGF-binding protein 6, IGFBP-6, Igfbp6, IBP6, IGF binding protein 6, insulin-like growth factor-binding protein 6
- Poids moléculaire
- 23.7 kDa
- UniProt
- P47880
- Pathways
- Signalisation WNT, Myometrial Relaxation and Contraction
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