ILKAP Protein (His tag)

N° du produit ABIN7317343

Détail du produit

Antigène: ILKAP (Integrin-Linked Kinase-Associated Serine/threonine Phosphatase 2C (ILKAP))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette ILKAP protéine est marqué à la His tag.

Fonction: Recombinant Human ILKAP Protein (His Tag)

Séquence: Met 1-His 392

Attributs du produit: A DNA sequence encoding the human ILKAP (Q9H0C8) (Met 1-His 392) was expressed, with a C-terminal polyhistidine tag.

Pureté: > 92 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: ILKAP (Integrin-Linked Kinase-Associated Serine/threonine Phosphatase 2C (ILKAP))

Autre désignation: ILKAP (ILKAP Produits)

Synonymes: MGC84595 Protein, MGC107938 Protein, ILKAP Protein, ILKAP2 Protein, ILKAP3 Protein, PP2C-DELTA Protein, 0710007A14Rik Protein, 1600009O09Rik Protein, ILK associated serine/threonine phosphatase Protein, ILK associated serine/threonine phosphatase L homeolog Protein, integrin-linked kinase-associated serine/threonine phosphatase Protein, integrin-linked kinase-associated serine/threonine phosphatase 2C Protein, ILKAP Protein, ilkap.L Protein, ilkap Protein, Ilkap Protein

Sujet:

Background: Integrin-linked kinase-associated serine/threonine phosphatase 2C, also known as ILKAP, is cytoplasm protein which belongs to the PP2C family. ILKAP contains one PP2C-like domain. ILKAP is widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues. ILKAP may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. ILKAP selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. ILKAP inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation. Integrin-linked kinase ( ILK ) plays key roles in a variety of cell functions, including cell proliferation, adhesion and migration. Within the cell, ILK localizes to multiple sites, including the cytoplasm, focal adhesion complexes that mediate cell adhesion to extracellular substrates, as well as cell-cell junctions in epidermal keratinocytes. Nuclear ILK can be rapidly exported into the cytoplasm through a CRM1-dependent pathway, and its export is enhanced by the type 2C protein phosphatase ILKAP. Nuclear localization of ILK in epidermal keratinocytes is associated with increased DNA synthesis, which is sensitive to inhibition by ILKAP.

Synonym: ILKAP2;ILKAP3;PP2C-DELTA

Poids moléculaire: 44.3 kDa

UniProt: Q9H0C8