IFNAR1 Protein (His tag)

N° du produit ABIN7318636

Détail du produit

Antigène: IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette IFNAR1 protéine est marqué à la His tag.

Fonction: Recombinant Human IFNAR1/IFNAR Protein (His Tag)(Active)

Séquence: Lys28-Lys436

Attributs du produit: Recombinant Human Interferon alpha/beta Receptor 1 is produced by our Mammalian expression system and the target gene encoding Lys28-Lys436 is expressed with a 6His tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Immobilized Human IFN alpha2b(Cat: PKSH033640) at 2μg/ml(100 μl/well) can bind Human IFNAR1-His.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))

Autre désignation: IFNAR1/IFNAR (IFNAR1 Produits)

Synonymes: ifnar1 Protein, IFNAR1 Protein, CD118 Protein, Ifar Protein, Ifnar Protein, Ifrc Protein, Infar Protein, AVP Protein, IFN-alpha-REC Protein, IFNAR Protein, IFNBR Protein, IFRC Protein, IFN-R-1 Protein, interferon alpha and beta receptor subunit 1 Protein, interferon-alpha/beta receptor alpha chain-like Protein, interferon (alpha and beta) receptor 1 Protein, interferon alpha/beta receptor 1 Protein, IFNAR1 Protein, ifnar1 Protein, Ifnar1 Protein, LOC609830 Protein

Sujet:

Background: The Interferon-α/β Receptor 1 (IFN-α/β R1) is a receptor which binds Type I Interferons including Interferon-α and -β. It is a cell surface receptor and heteromeric receptor composed of one chain with two subunits referred to as IFNAR1 and IFNAR2. IFN-α/β R1, in association with IFN-α/β R2, is required for propagating antiviral signal transduction triggered by IFN-α and IFN-β. IFN-α/β R1 interacts very weakly or not at all with type 1 interferons and does not stably interact with IFN-α/β R2. Ligands associate with IFN-α/β R2, and this complex subsequently forms a stable ternary assembly with IFN-α/β R1. IFN-α/β R1 also associates with IFN-γ R2 even in the absence of IFN-γ stimulation. Human IFN-α/β R1 contains a nuclear localization signal in its extracellular domain that is required for receptor translocation to the nucleus following interaction with ligand. Interferon stimulation results in an immunologic response that is especially associated with viruses.

Synonym: Interferon Alpha/Beta Receptor 1, IFN-R-1, IFN-Alpha/Beta Receptor 1, Cytokine Receptor Class-II Member 1, Cytokine Receptor Family 2 Member 1, CRF2-1, Type I Interferon Receptor 1,IFNAR1,IFNAR,AVP,IFN-alpha-REC

Poids moléculaire: 48.2 kDa

UniProt: P17181

Pathways: Signalistation JAK/STAT, Hepatitis C