IL17RA Protein (Fc Tag)
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- Antigène Voir toutes IL17RA Protéines
- IL17RA (Interleukin 17 Receptor A (IL17RA))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
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Origine
- Rat
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette IL17RA protéine est marqué à la Fc Tag.
- Fonction
- Recombinant Rat IL17RA Protein (Fc Tag)(Active)
- Séquence
- Met1-Pro320
- Attributs du produit
- A DNA sequence encoding the rat IL17RA (NP_001101353.2)(Met1-Pro320) was expressed with the Fc region of human IgG1 at the C-terminus.
- Pureté
- > 95 % as determined by SDS-PAGE
- niveau d'endotoxine
- < 1.0 EU per μg of the protein as determined by the LAL method
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA.Immobilized mouse Il17A at 10 μg/ml (100 μl/well) can bind Rat IL17RA, The EC50 of RatIL17RA is 12.0-29.0 ng/ml.
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- Discover our top product IL17RA Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Antigène
- IL17RA (Interleukin 17 Receptor A (IL17RA))
- Autre désignation
- IL17RA (IL17RA Produits)
- Synonymes
- IL17R Protein, CANDF5 Protein, CD217 Protein, CDw217 Protein, IL-17RA Protein, hIL-17R Protein, Il17r Protein, AW538159 Protein, Cdw217 Protein, VDw217 Protein, interleukin 17 receptor A Protein, IL17RA Protein, Il17ra Protein
- Sujet
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Background: Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
Synonym: IL17RA
- Poids moléculaire
- 59.7 kDa
- NCBI Accession
- NP_001101353
- Pathways
- SARS-CoV-2 Protein Interactome
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