IL20RA Protein (His tag)

N° du produit ABIN7317883

Détail du produit

Antigène: IL20RA (Interleukin 20 Receptor alpha (IL20RA))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette IL20RA protéine est marqué à la His tag.

Fonction: Recombinant Human IL-20RA/IL-20R1 Protein (His Tag)

Séquence: Met 1-Lys 250

Attributs du produit: A DNA sequence encoding the extracellular domain of human IL20Rα isoform 1 (NP_055247.21) (Met 1-Lys 250) was fused with a polyhistidine tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.2

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: IL20RA (Interleukin 20 Receptor alpha (IL20RA))

Autre désignation: IL-20RA/IL-20R1 (IL20RA Produits)

Synonymes: CRF2-8 Protein, IL-20R-alpha Protein, IL-20R1 Protein, IL-20RA Protein, E230031K19 Protein, interleukin 20 receptor subunit alpha Protein, interleukin 20 receptor, alpha Protein, IL20RA Protein, Il20ra Protein

Sujet:

Background: Interleukin 20 receptor, alpha subunit (IL20RA/IL-20RA) also known as IL-20 receptor subunit alpha, Cytokine receptor class-II member 8, interleukin-20 receptor I, and interleukin-20 receptor subunit alpha, is a subunit for the interleukin-20 receptor. IL20RA/IL-20RA belongs to the type II cytokine receptor family. This cytokine is a receptor for interleukin 20 (IL20), a cytokine that may be involved in epidermal function. The receptor of IL20 is a heterodimeric receptor complex consisting of this protein and interleukin 20 receptor beta (IL20B). IL20RA forms heterodimer with IL20RB, and the complex serves as a receptor for IL19, IL20 and IL24. All three are capable of signaling through IL-20RA/IL-20RB complex. The ligand binding to receptor B creating a high-affinity binding site for the receptor A which is recruited to complete the complex. In addition, IL20RA also forms a heterodimer with the unique and specific receptor IL10RB and functions as the receptor for IL26. IL20RA is widely expressed with highest levels in skin, testis and brain. The expression of both IL20RA and IL20RB is found to be upregulated in psoriatic skin lesions on keratinocytes.

Synonym: Interleukin-20 Receptor Subunit Alpha, IL-20 Receptor Subunit Alpha, IL-20R-Alpha, IL-20RA, Cytokine Receptor Class-II Member 8, Cytokine Receptor Family 2 Member 8, CRF2-8, IL-20R1, ZcytoR7, IL20RA

Poids moléculaire: 26.8 kDa