IL22 Receptor alpha 1 Protein (Fc Tag,ECD)

N° du produit ABIN7196511

Détail du produit

Antigène: IL22 Receptor alpha 1 (IL22RA1) (Interleukin 22 Receptor, alpha 1 (IL22RA1))

Type de proteíne: Recombinant

Origine: Rat

Source: HEK-293 Cells

Purification/Conjugué: Cette IL22 Receptor alpha 1 protéine est marqué à la Fc Tag,ECD.

Fonction: Recombinant Rat IL-22R/IL22RA1 Protein (ECD, Fc Tag)

Séquence: Met1-Ala228

Attributs du produit: A DNA sequence encoding the rat Il22ra1 (NP_001178798.1) (Met1-Ala228) was expressed with the Fc region of human IgG1 at the C-terminus.

Pureté: > 95 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: IL22 Receptor alpha 1 (IL22RA1) (Interleukin 22 Receptor, alpha 1 (IL22RA1))

Autre désignation: IL-22R/IL22RA1 (IL22RA1 Produits)

Synonymes: IL22RA1 Protein, CRF2-9 Protein, IL22R Protein, IL22R1 Protein, 9130219A07Rik Protein, ENSMUSG00000073746 Protein, IL-22R Protein, Il22r Protein, RGD1559655 Protein, interleukin 22 receptor subunit alpha 1 Protein, interleukin 22 receptor, alpha 1 Protein, IL22RA1 Protein, Il22ra1 Protein

Sujet:

Background: IL-22R belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains and is expressed in colon, liver, lung, pancreas and kidney. IL-22R also can be expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Overexpression of IL-22R can be detected in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients. IL-22R is a component of the receptor for IL20, IL22 and IL24. The component of IL-22R formed by IL22RA1 and IL10RB enables IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. IL-22R mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.

Synonym: IL-22R, IL22RA1

Poids moléculaire: 50.8 kDa

NCBI Accession: NP_001178798