LAMTOR2 Protein (His tag)

N° du produit ABIN7317349

Détail du produit

Antigène: LAMTOR2 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 2 (LAMTOR2))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette LAMTOR2 protéine est marqué à la His tag.

Fonction: Recombinant Human LAMTOR2/ROBLD3/MAPBPIP Protein (His Tag)

Séquence: Met 1-Ser 125

Attributs du produit: A DNA sequence encoding the mature form of human LAMTOR2 isoform 1 (Q9Y2Q5-1) (Met 1-Ser 125) was expressed, with a polyhistide tag at the N-terminus.

Pureté: > 97 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: LAMTOR2 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 2 (LAMTOR2))

Autre désignation: LAMTOR2/ROBLD3/MAPBPIP (LAMTOR2 Produits)

Synonymes: ENDAP Protein, HSPC003 Protein, MAPBPIP Protein, MAPKSP1AP Protein, ROBLD3 Protein, Ragulator2 Protein, p14 Protein, 2010111E04Rik Protein, AL022628 Protein, Mapbpip Protein, P14 Protein, Rab25 Protein, Robld3 Protein, RGD1562501 Protein, cg5189 Protein, endap Protein, hspc003 Protein, mapbpip Protein, mapbpip-B Protein, mapksp1ap Protein, ragulator2 Protein, robld3 Protein, robld3-b Protein, zgc:100811 Protein, lamtor2 Protein, lamtor2-a Protein, lamtor2-b Protein, mapbpip-A Protein, robld3-a Protein, late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 Protein, late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 S homeolog Protein, late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 L homeolog Protein, LAMTOR2 Protein, Lamtor2 Protein, lamtor2.S Protein, lamtor2 Protein, lamtor2.L Protein

Sujet:

Background: Ragulator complex protein LAMTOR2, also known as Endosomal adaptor protein p14, Late endosomal / lysosomal Mp1-interacting protein, Late endosomal / lysosomal adaptor and MAPK and MTOR activator 2, Mitogen-activated protein-binding protein-interacting protein, Roadblock domain-containing protein 3, LAMTOR2, MAPBPIP and ROBLD3, is a protein which belongs to the GAMAD family. LAMTOR2 / ROBLD3 is a regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, LAMTOR2 / ROBLD3 recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids. LAMTOR2 / ROBLD3 is an adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. Defects in LAMTOR2 are the cause of immunodeficiency due to defect in MAPBP-interacting protein (ID-MAPBPIP). This form of primary immunodeficiency syndrome includes congenital neutropenia, partial albinism, short stature and B-cell and cytotoxic T-cell deficiency.

Synonym: ENDAP;HSPC003;MAPBPIP;MAPKSP1AP;p14;Ragulator2;ROBLD3;RP11-336K24.9

Poids moléculaire: 15 kDa

Pathways: Signalisation PI3K-Akt