LTBR Protein (His tag)

N° du produit ABIN7321202

Détail du produit

Antigène: LTBR (Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR))

Type de proteíne: Recombinant

Origine: Rat

Source: HEK-293 Cells

Purification/Conjugué: Cette LTBR protéine est marqué à la His tag.

Fonction: Recombinant Rat LTBR/TNFRSF3 Protein (His Tag)

Séquence: Met 1-Ala 218

Attributs du produit: A DNA sequence encoding the rat LTBR (NP_001008316.1) extracellular domain (Met 1-Ala 218) was expressed, fused with a polyhistidine tag at the C-terminus.

Pureté: > 96 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: LTBR (Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR))

Autre désignation: LTBR/TNFRSF3 (LTBR Produits)

Synonymes: AI256028 Protein, CD18 Protein, LTbetaR Protein, Ltar Protein, TNF-R-III Protein, TNFCR Protein, TNFR-RP Protein, TNFR2-RP Protein, TNFRrp Protein, Tnfbr Protein, Tnfrsf3 Protein, D12S370 Protein, LT-BETA-R Protein, TNFR3 Protein, TNFRSF3 Protein, lymphotoxin beta receptor Protein, lymphotoxin B receptor Protein, Ltbr Protein, LTBR Protein

Sujet:

Background: LTBR (lymphotoxin beta receptor (TNFR superfamily, member 3)) is a member of the tumor necrosis factor (TNF) family of receptors. Tumor necrosis factor receptor is a trimeric cytokine receptor that binds tumor necrosis factors. The receptor cooperates with an adaptor protein (such as TRADD, TRAF, RIP), which is important in determining the outcome of the response. LTBR is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. LTBR specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). LTBR and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of this protein can trigger apoptosis. Not only does the LTBR help trigger apoptosis, it can lead to the release of the cytokine interleukin 8. Overexpression of LTBR in HEK293 cells increases IL-8 promoter activity and leads to IL-8 release. It is also essential for development and organization of the secondary lymphoid organs and chemokine release.

Synonym: LTBR

Poids moléculaire: 23 kDa

NCBI Accession: NP_001008316

Pathways: Signalisation NF-kappaB