METAP2 Protein (His tag)

N° du produit ABIN7318776

Détail du produit

Antigène: METAP2 (Methionyl Aminopeptidase 2 (METAP2))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette METAP2 protéine est marqué à la His tag.

Fonction: Recombinant Human METAP2 Protein (His Tag)

Séquence: Ala2-Tyr478

Attributs du produit: Recombinant Human Methionine Aminopeptidase 2 is produced by our Baculovirus expression system and the target gene encoding Ala2-Tyr478 is expressed with a 6His tag at the N-terminus.

Pureté: > 90 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 8.0 .

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: METAP2 (Methionyl Aminopeptidase 2 (METAP2))

Autre désignation: METAP2 (METAP2 Produits)

Synonymes: metap2 Protein, MGC53792 Protein, METAP2 Protein, GB13458 Protein, DDBDRAFT_0190923 Protein, DDBDRAFT_0304991 Protein, DDB_0190923 Protein, DDB_0304991 Protein, 4930584B20Rik Protein, A930035J23Rik Protein, AI047573 Protein, AL024412 Protein, AU014659 Protein, Amp2 Protein, Mnpep Protein, p67 Protein, p67eIF2 Protein, MAP2 Protein, MNPEP Protein, wu:fb98h06 Protein, zgc:66250 Protein, methionyl aminopeptidase 2 L homeolog Protein, methionyl aminopeptidase 2 Protein, methionine aminopeptidase 2 Protein, methionine aminopeptidase Protein, methionyl aminopeptidase 2 S homeolog Protein, methionyl aminopeptidase 2b Protein, metap2.L Protein, METAP2 Protein, metap2 Protein, LOC551771 Protein, CAALFM_C604080WA Protein, Metap2 Protein, metap2.S Protein, metap2b Protein

Sujet:

Background: Human Methionine Aminopeptidase 2 (METAP2, MAP2) is a member of the M24 family of metalloproteases. METAPs catalyze the removal of the initiator methionine residue from nascent peptides and are essential for cell growth. MAP2 binds 2 cobalt or manganese ions and contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. It is found in all organisms and is especially important because of its critical role in tissue repair and protein degradation. METAP2 plays an important role in the development of different types of cancer and has been a novel target for developing anti-cancer drugs. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amno-terminal methionine residue from nascent protein. MAP2 protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. It also plays a critical role in the regulation of protein synthesis.

Synonym: Methionine aminopeptidase 2, MAP 2, MetAP 2, p67, p67eIF2, Peptidase M, METAP2, MAP2

Poids moléculaire: 53.6 kDa

UniProt: P50579

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling