OPCML Protein (AA 5-313) (His tag)

N° du produit ABIN7320058

Détail du produit

Antigène: OPCML (Opioid Binding Protein/cell Adhesion Molecule-Like (OPCML))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 5-313

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette OPCML protéine est marqué à la His tag.

Fonction: Recombinant Mouse OBCAM/OPCML Protein (aa 5-313, His Tag)(Active)

Séquence: Ala5-Val313

Attributs du produit: A DNA sequence encoding the mouse OPCML (NP_808574.2) (Ala5-Val313) was expressed with a C-terminal polyhistidine tag.

Pureté: > 95 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: 1. Measured by its binding ability in a functional ELISA.2. Immobilized mouse OPCmL-His at 10μg/mL (100μL/well) can bind human LSAMP-Fc .The EC50 of human LSAMP-Fc is 0.04-0.1 μg/mL.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: OPCML (Opioid Binding Protein/cell Adhesion Molecule-Like (OPCML))

Autre désignation: OBCAM/OPCML (OPCML Produits)

Synonymes: IGLON1 Protein, OBCAM Protein, OPCM Protein, 2900075O15Rik Protein, 3732419F12 Protein, AI844366 Protein, B930023M13Rik Protein, C230027C17 Protein, Gm181 Protein, Obcam Protein, opioid binding protein/cell adhesion molecule like Protein, opioid binding protein/cell adhesion molecule-like Protein, OPCML Protein, Opcml Protein

Sujet:

Background: Opioid-binding Cell Adhesion Molecule (OBCAM), also known as OPCML, is a GPI-anchored cell adhesion molecule in the plasma membrane. This neuron-specific protein, consists of three immunoglobulin (Ig)-like domains anchored to the membrane through a glycosylphosphatidylinositol (GPI)-tail. OPCML also belongs to the member of the IgLON family, a subgroup of the immunoglobulin superfamily, consisting of three members, LAMP, OBCAM, and Neurotrimin. These molecules interact homophilically and heterophilically within the family, and OBCAM acts only as heterodimers with LAMP or Neurotrimin and possibly inhibits neurite outgrowth from cerebellar granule cells. OBCAM has been presumed to play a role as a cell adhesion/recognition molecule. Furthermore, the OPCML protein defects may play an important role in the carcinogenesis of cervical or ovarian cancers, and this gene is regarded as a candidate TSG (tumor suppressor gene).

Synonym: 2900075O15Rik,3732419F12,AI844366,B930023M13Rik,C230027C17,Gm181,Obcam,B-CAM,Gplu,Lu

Poids moléculaire: 32.7 kDa

NCBI Accession: NP_808574