PLA2G1B Protein (His tag)

N° du produit ABIN7320793

Détail du produit

Antigène: PLA2G1B (Phospholipase A2, Group IB (PLA2G1B))

Type de proteíne: Recombinant

Origine: Souris

Source: Human Cells

Purification/Conjugué: Cette PLA2G1B protéine est marqué à la His tag.

Fonction: Recombinant Mouse PLA2G1B/PLA2 Protein (His Tag)

Séquence: Ala16-Cys146

Attributs du produit: Recombinant Mouse Phospholipase A2 is produced by our Mammalian expression system and the target gene encoding Ala16-Cys146 is expressed with a 6His tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM HEPES,150 mM NaCl, pH 7.0.

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: PLA2G1B (Phospholipase A2, Group IB (PLA2G1B))

Autre désignation: PLA2G1B/PLA2 (PLA2G1B Produits)

Synonymes: C133 Protein, CG4346 Protein, Dmel\\CG42237 Protein, Dmel_CG4346 Protein, PLA2 Protein, GB13351 Protein, bvPLA2 Protein, PLA2A Protein, PPLA2 Protein, sPLA(2)-IB Protein, Pla2a Protein, sPLA2IB Protein, PLA2G1B Protein, CG42237 gene product from transcript CG42237-RB Protein, phospholipase A2 Protein, phospholipase A2 group IB Protein, phospholipase A2, group IB, pancreas Protein, phospholipase A2 group IVA Protein, CG42237 Protein, PLA2 Protein, LOC100631065 Protein, Pla2 Protein, PLA2G1B Protein, Pla2g1b Protein, PLA2G4A Protein

Sujet:

Background: Mouse phospholipase A2 is a secreted protein which belongs to the phospholipase A2 family. Phospholipase A2/PLA2G1B catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. PLA2G1B has been thought to play major role in digestion of glycerophospholipids in nutrients, given its abundance in digestive organs. Since its expression has been observed in non-digestive organs including the lung, spleen, kidney, ovary, retina, brain, and neurons, its function may not limited to digestive role. PLA2G1B are resistant to obesity and diabetes induced by feeding a diabetogenic high-fat/high-carbohydrate diet. PLA2G1B inhibition may be a potentially effective oral therapeutic option for treatment of obesity and diabetes.

Synonym: Phospholipase A2, Group IB phospholipase A2, PLA2-Ib, Phosphatidylcholine 2-acylhydrolase 1B, Pla2g1b, Pla2

Poids moléculaire: 15.6 kDa

UniProt: Q9Z0Y2

Pathways: Inositol Metabolic Process, VEGF Signaling