PF4 Protein (His tag)
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- Antigène Voir toutes PF4 Protéines
- PF4 (Platelet Factor 4 (PF4))
- Type de proteíne
- Recombinant
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Origine
- Humain
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Source
- Human Cells
- Purification/Conjugué
- Cette PF4 protéine est marqué à la His tag.
- Fonction
- Recombinant Human CXCL4/PF4 Protein (His Tag)
- Séquence
- Glu32-Ser101
- Attributs du produit
- Recombinant Human C-X-C Motif Chemokine 4/Platelet Factor 4 is produced by our Mammalian expression system and the target gene encoding Glu32-Ser101 is expressed with a 6His tag at the C-terminus.
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
- niveau d'endotoxine
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product PF4 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
- Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Antigène
- PF4 (Platelet Factor 4 (PF4))
- Autre désignation
- CXCL4/PF4 (PF4 Produits)
- Synonymes
- CXCL4 Protein, PF-4 Protein, SCYB4 Protein, Cxcl4 Protein, Scyb4 Protein, Pf4a Protein, RATPF4A Protein, PF4A Protein, CXCL4L1 Protein, CXCL4V1 Protein, PF4-ALT Protein, SCYB4V1 Protein, PF4 Protein, platelet factor 4 Protein, platelet factor 4 variant 1 Protein, PF4 Protein, Pf4 Protein, LOC703451 Protein, PF4V1 Protein, LOC100524373 Protein, LOC102181854 Protein, LOC100630489 Protein
- Sujet
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Background: Human Chemokine (C-X-C motif) Ligand 4 (CXCL4) is expressed in megakaryocytes and stored in the alpha-granules of platelets. CXCL4 contains several heparin-binding sites at the C-terminal region and binds heparin with high affinity. The active CXCL4 protein is a tetramer. Human and mouse CXCL4 share 64 % sequence identity. CXCL4 is chemotactic for neutrophils, fibroblasts and monocytes and plays a critical role in inflammation and wound repair. CXCL4 functions via a splice variant of the chemokine receptor CXCR3, known as CXCR3B. The major physiologic role of CXCL4 appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. In contrast to other CXC chemokines, CXCL4 lacks chemotactic activity for polymorphonuclear granulocytes.
Synonym: Platelet Factor 4, PF-4, C-X-C Motif Chemokine 4, Iroplact, Oncostatin-A, PF4, CXCL4, SCYB4
- Poids moléculaire
- 8.5 kDa
- UniProt
- P02776
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