PVRIG Protein (mFc Tag)

N° du produit ABIN7319903

Détail du produit

Antigène: PVRIG (Poliovirus Receptor-Related Immunoglobulin Domain Containing (PVRIG))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette PVRIG protéine est marqué à la mFc Tag.

Fonction: Recombinant Human PVRIG (C-mFc)

Séquence: Thr41-Asp171

Attributs du produit: Recombinant Human Transmembrane Protein PVRIG is produced by our Mammalian expression system and the target gene encoding Thr41-Asp171 is expressed with a mFc tag at the C-terminus.

Pureté: >95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: 1.Immobilized Human PVRIG-mFc(Cat#C08Y) at 10μg/ml (100 μl/well) can bind Human Nectin-2-His(Cat#C440).The ED50 of Human Nectin-2-His(Cat#C440) is 3.72 ug/ml. 2.Immobilized Human PVRIG-mFc(Cat#C08Y) at 10μg/ml (100 μl/well) can bind Biotinylated Human Nectin-2-His-Avi(Cat#CY73). The ED50 of Biotinylated Human Nectin-2-His-Avi(Cat#CY73) is 0.42 ug/ml.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: PVRIG (Poliovirus Receptor-Related Immunoglobulin Domain Containing (PVRIG))

Autre désignation: PVRIG (PVRIG Produits)

Synonymes: C7orf15 Protein, PVR related immunoglobulin domain containing Protein, PVRIG Protein

Sujet:

Background: Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The extracellular domain sequence of human and mouse PVRIG have approximately 65 % similarity. PVRIG functions as a cell surface receptor for Nectin-2/CD112, a cell surface protein that is widely expressed on antigen-presenting cells and tumor cells. Disrupting the PVRIG/Nectin-2 interaction enhances human T cell response, suggesting PVRIG is a novel checkpoint for human T cells. PVRIG may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.

Synonym: C7orf15, CD112R, PVRIG, transmembrane protein PVRIG, C7orf15MGC138295, MGC104322, MGC138297, MGC2463

Poids moléculaire: 40.1 kDa

UniProt: Q6DKI7