CD133 Protein (His tag)

N° du produit ABIN7321128

Détail du produit

Antigène: CD133 (PROM1) (Prominin 1 (PROM1))

Type de proteíne: Recombinant

Origine: Rat

Source: HEK-293 Cells

Purification/Conjugué: Cette CD133 protéine est marqué à la His tag.

Fonction: Recombinant Rat CD133/PROM1/Prominin 1 Protein (His Tag)

Séquence: Asn171-Tyr424

Attributs du produit: A DNA sequence encoding the rat PROM1 (NP_001103607.1) (Asn171-Tyr424) was expressed with a polyhistidine tag at the N-terminus.

Pureté: > 90 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: CD133 (PROM1) (Prominin 1 (PROM1))

Autre désignation: CD133/PROM1/Prominin 1 (PROM1 Produits)

Synonymes: Prom Protein, AC133 Protein, CD133 Protein, Prom-1 Protein, Proml1 Protein, 4932416E19Rik Protein, CORD12 Protein, MCDR2 Protein, PROML1 Protein, RP41 Protein, STGD4 Protein, prominin 1 Protein, Prom1 Protein, PROM1 Protein

Sujet:

Background: CD133, also known as PROM1 and Prominin 1, is a pentaspan transmembrane glycoprotein which belongs to the prominin family. It localizes to membrane protrusions and is often expressed on adult stem cells. CD133 is known to play a role in maintaining stem cell properties by suppressing differentiation. CD133 binds cholesterol in cholesterol-containing plasma membrane microdomains. It is proposed to play a role in apical plasma membrane organization of epithelial cells. CD133 is also involved in regulation of MAPK and Akt signaling pathways. Mutations in PROM1 gene have been shown to result in retinitis pigmentosa and Stargardt disease. PROM1 gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Expression of this gene is also associated with several types of cancer.

Synonym: PROM1

Poids moléculaire: 30.9 kDa

UniProt: F1MAN1