PCSK1 Protein (His tag)

N° du produit ABIN7197525

Détail du produit

Antigène: PCSK1 (Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette PCSK1 protéine est marqué à la His tag.

Fonction: Recombinant Human PCSK1/NEC1 Protein (His Tag)

Séquence: Met 1-Arg 617

Attributs du produit: A DNA sequence encoding the human PCSK1 (NP_000430.3) (Met 1-Arg 617) was fused with a polyhistidine tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 25 mM Tris, 150 mM NaCl, pH 7.5

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: PCSK1 (Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1))

Autre désignation: PCSK1/NEC1 (PCSK1 Produits)

Synonymes: BMIQ12 Protein, NEC1 Protein, PC1 Protein, PC3 Protein, SPC3 Protein, Nec-1 Protein, Nec1 Protein, Phpp-1 Protein, BDP Protein, PC1/3 Protein, proprotein convertase subtilisin/kexin type 1 Protein, prohormone convertase 1 Protein, PCSK1 Protein, Pcsk1 Protein, pcsk1 Protein, PC1B Protein

Sujet:

Background: Neuroendocrine convertase 1, also known as Prohormone convertase 1, Proprotein convertase 1, PCSK1 and NEC1, is an enzyme which belongs to the peptidase S8 family and Furin subfamily. PCSK1 is an enzyme that performs the proteolytic cleavage of prohormones to their intermediate (or sometimes completely cleaved) forms. It is present only in neuroendocrine cells such as brain, pituitary and adrenal, and most often cleaves after a pair of basic residues within prohormones but can occasionally cleave after a single arginine. It binds to a protein known as proSAAS, which also represents its endogenous inhibitor. PCSK1 is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. PCSK1 substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin. Defects in PCSK1 are the cause of proprotein convertase 1 deficiency (PC1 deficiency). PC1 deficiency is characterized by obesity, hypogonadism, hypoadrenalism, reactive hypoglycemia as well as marked small-intestinal absorptive dysfunction. It is due to impaired processing of prohormones.

Synonym: BMIQ12;NEC1;PC1;PC3;SPC3

Poids moléculaire: 57.4 kDa

NCBI Accession: NP_000430

Pathways: Peptide Hormone Metabolism