RTN4R Protein (His tag,Fc Tag)

N° du produit ABIN7317859

Détail du produit

Antigène: RTN4R (Reticulon 4 Receptor (RTN4R))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette RTN4R protéine est marqué à la His tag,Fc Tag.

Fonction: Recombinant Human Nogo Receptor/NgR Protein (His & Fc Tag)(Active)

Séquence: Met 1-Ser 447

Attributs du produit: A DNA sequence encoding the mature form of human RTN4R (NP_075380.1) (Met 1-Ser 447) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.

Pureté: > 90 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Measured by its ability to bind recombinant human RTN4 in a functional ELISA.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: RTN4R (Reticulon 4 Receptor (RTN4R))

Autre désignation: Nogo Receptor/NgR (RTN4R Produits)

Synonymes: NgR Protein, NGR Protein, NOGOR Protein, NgR1 Protein, Nogor Protein, reticulon 4 receptor Protein, rtn4r Protein, RTN4R Protein, Rtn4r Protein

Sujet:

Background: Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 10 LRP (Leucine-rich) repeats. RTN4R is expressed predominantly in neurons and their axons in the central nervous systems (CNS). As a receptor for myelin-derived proteins Nogo, myelin-associated glycoprotein (MAG), and myelin oligodendrocyte glycoprotein (OMG), RTN4R mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult CNS. It has been shown that RTN4R performs its inhibitory actions by interacting with the p75 neurotrophin receptor (p75NTR), a TNFRSF member also known for modulating the activities of the Trk family and for inducing apoptosis in neurons and oligodendrocytes. RTN4R may be proposed as a potential drug target for treatment of various neurological conditions such as spinal cord injury, CNS lesions, peripheral nerve injury, stroke and Alzheimer's disease (AD). Additionally, RTN4R may play a role in regulating the function of the gap junctions.

Synonym: Reticulon-4 Receptor, Nogo Receptor, NgR, Nogo-66 Receptor, RTN4R, NOGOR

Poids moléculaire: 73 kDa

NCBI Accession: NP_075380

Pathways: Neurotrophin Signaling Pathway