S100A11 Protein (His tag)

N° du produit ABIN7320359

Détail du produit

Antigène: S100A11 (S100 Calcium Binding Protein A11 (S100A11))

Type de proteíne: Recombinant

Origine: Souris

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette S100A11 protéine est marqué à la His tag.

Fonction: Recombinant Mouse S100A11 Protein (His Tag)

Séquence: Met1-Ile98

Attributs du produit: A DNA sequence encoding the mouse S100A11 (NP_058020.1) (Met1-Ile98) was expressed with a polyhistidine tag at the N-terminus.

Pureté: > 90 % as determined by SDS-PAGE

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, 10 % glycerol, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: S100A11 (S100 Calcium Binding Protein A11 (S100A11))

Autre désignation: S100A11 (S100A11 Produits)

Synonymes: MLN70 Protein, S100C Protein, PCALG Protein, EMAPI Protein, Emap1 Protein, S100a14 Protein, S100c Protein, cal Protein, S100 calcium binding protein A11 Protein, S100A11 Protein, S100a11 Protein

Sujet:

Background: Protein S100-A11, also known as S100 calcium-binding protein A11, S100A11 and MLN70, is a member of the S-100 family. S100A11 is widely expressed in multiple tissues, and is located in cytoplasm, nucleus, and even cell periphery. S100A11 exists as a non-covalent homodimer with an antiparallel conformation. Ca(2+) binding to S100A11 would trigger conformational changes which would expose the hydrophobic cleft of S100A11 and facilitate its interaction with target proteins. As a dual cell growth mediator, S100A11 acts as either a tumor suppressor or promoter in many different types of tumors and would play respective roles in influencing the proliferation of the cancer cells. In the nucleus, S100A11 suppresses the growth of keratinocytes through p21 (CIP1/WAF1) activation and induces cell differentiation. S100A11 is also a novel diagnostic marker in breast carcinoma.

Synonym: Protein S100-A11; Calgizzarin; Endothelial monocyte-activating polypeptide; EMAP; Protein S100-C; S100 calcium-binding protein A11; S100a11; S100c;cal;Emap1;EMAPI;S100A11;S100a14;S100c

Poids moléculaire: 13.2 kDa

NCBI Accession: NP_058020

Pathways: S100 Proteins