SLPI Protein (AA 1-132) (His tag)
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- Antigène Voir toutes SLPI Protéines
- SLPI (Secretory Leukocyte Peptidase Inhibitor (SLPI))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 1-132
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Origine
- Humain
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Source
- Baculovirus infected Insect Cells
- Purification/Conjugué
- Cette SLPI protéine est marqué à la His tag.
- Fonction
- Recombinant Human SLPI Protein (aa 1-132, His Tag)(Active)
- Séquence
- Met 1-Ala132
- Attributs du produit
- A DNA sequence encoding the human SLPI (P03973)( Met1-Ala132) was expressed, with a C-terminal polyhistidine tag.
- Pureté
- > 90 % as determined by reducing SDS-PAGE.
- niveau d'endotoxine
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to inhibit trypsin cleavage of a fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK (Dnp)-NH2 (Catalog # ES002).The IC50 value is <1 Nm.
- Top Product
- Discover our top product SLPI Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 7.4
- Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Antigène
- SLPI (Secretory Leukocyte Peptidase Inhibitor (SLPI))
- Autre désignation
- SLPI (SLPI Produits)
- Synonymes
- ALK1 Protein, ALP Protein, BLPI Protein, HUSI Protein, HUSI-I Protein, MPI Protein, WAP4 Protein, WFDC4 Protein, MATN4 Protein, SLPI Protein, ckpi Protein, secretory leukocyte peptidase inhibitor Protein, antileukoproteinase Protein, SLPI Protein, Slpi Protein, LOC102174044 Protein
- Sujet
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Background: Secretory leukoprotease inhibitor (SLPI), also called antileukoprotease (ALP), is a 12- kDa, nonglycosylated serine protease inhibitor present in mucous secretions. It is thought to play a role in protecting the mucosae from injury associated with inflammation. SLPI is locally produced by serous cells, including bronchial submucosal glands. Elafin and SLPI are members of larger families of proteins secreted predominantly at mucosal sites, and have been shown to be modulated in multiple pathological conditions. Elafin and SLPI are structurally related in that both have a fold with a four-disulfide core or whey acidic protein (WAP) domain responsible for inhibiting proteases. SLPI is a prominent innate immune protein of the respiratory tract, possessing serine protease inhibitor activity, antibacterial activity, and anti-inflammatory/immunomodulatory activity.
Synonym: ALK1,ALP,BLPI,HUSI,HUSI-I,MPI,WAP4,WFDC4
- Poids moléculaire
- 13.1 kDa
- UniProt
- P03973
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