SH2D1A Protein (His tag)
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- Antigène Voir toutes SH2D1A Protéines
- SH2D1A (SH2 Domain Containing 1A (SH2D1A))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
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Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette SH2D1A protéine est marqué à la His tag.
- Fonction
- Recombinant Human SH2D1A/SAP Protein (His Tag)(Active)
- Séquence
- Pro 2-Lys 97
- Attributs du produit
- A DNA sequence encoding the human SH2D1A isoform 1 (NP_002342.1) (Pro 2-Lys 97) was expressed, with a polyhistidine tag at the N-terminus.
- Pureté
- > 94 % as determined by reducing SDS-PAGE.
- Biological Activity Comment
- 1. Measured by its ability to bind recombinant human SLAMF1 in a functional ELISA.2. Measured by its ability to bind recombinant human SLAMF6 in a functional ELISA.3. Measured by its ability to bind recombinant mouse SLAMF6 in a functional ELISA.4. Measured by its ability to bind recombinant mouse CD84 in a functional ELISA.
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- Discover our top product SH2D1A Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.5, 20 % glycerol
- Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Antigène
- SH2D1A (SH2 Domain Containing 1A (SH2D1A))
- Autre désignation
- SH2D1A/SAP (SH2D1A Produits)
- Synonymes
- DSHP Protein, EBVS Protein, IMD5 Protein, LYP Protein, MTCP1 Protein, SAP Protein, SAP/SH2D1A Protein, XLP Protein, XLPD Protein, RGD1562408 Protein, Gm686 Protein, SH2D1A Protein, SH2 domain containing 1A Protein, SH2D1A Protein, Sh2d1a Protein
- Sujet
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Background: SH2 domain-containing protein 1A (SH2D1A / SAP) is a 128 amino acid protein, containing a single Src homology 2 (SH2) domain, flanked by 5 amino acids at the N-terminus and 25 amino acids at the C-terminus. The absence of a catalytic domain and the presence of an SH2 domain suggest that SH2D1A regulates one or more signal transduction pathways. SH2D1A interacts with signaling lymphocytic activation molecule (SLAM), which is a transmembrane protein expressed on the surface of activated T and B cells. SH2D1A (SAP) interacts via its SH2 domain with a motif (TIYXXV) present in the cytoplasmic tail of the cell-surface receptors, including CD150 / SLAM, CD84, CD229 / Ly-9, and CD244 / 2B4. SH2D1A was expressed in EBV-carrying, tumor phenotype representative (type I), but not in EBV-carrying lymphoblastoid cell line (LCL)-like (type III) or EBV-negative Burkitt lymphoma (BL) lines. It has been supposed to be related to the X-linked lymphoproliferative disease which is also known as Duncan's disease or Purtilo syndrome.
Synonym: SH2 Domain-Containing Protein 1A; Duncan Disease SH2-Protein; Signaling Lymphocytic Activation Molecule-Associated Protein; SLAM-Associated Protein; T-Cell Signal Transduction Molecule SAP; SH2D1A;DSHP;EBVS;IMD5;LYP;MTCP1;SAP/SH2D1A;XLP;XLPD;XLPD1
- Poids moléculaire
- 15.6 kDa
- NCBI Accession
- NP_002342
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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