SIGLEC8 Protein (His tag)
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- Antigène Voir toutes SIGLEC8 Protéines
- SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))
- Type de proteíne
- Recombinant
- Origine
- Humain
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Source
- Human Cells
- Purification/Conjugué
- Cette SIGLEC8 protéine est marqué à la His tag.
- Fonction
- Recombinant Human Siglec-8 (C-6His)
- Séquence
- Met17-Ala363
- Attributs du produit
- Recombinant Human Sialic Acid-binding Ig-like Lectin 8 is produced by our Mammalian expression system and the target gene encoding Met17-Ala363 is expressed with a 6His tag at the C-terminus.
- Pureté
- >95 % as determined by reducing SDS-PAGE.
- niveau d'endotoxine
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product SIGLEC8 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Antigène
- SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))
- Autre désignation
- Siglec-8 (SIGLEC8 Produits)
- Synonymes
- SAF2 Protein, SIGLEC-8 Protein, SIGLEC8L Protein, SIGLEC8 Protein, sialic acid binding Ig like lectin 8 Protein, sialic acid-binding Ig-like lectin 8 Protein, SIGLEC8 Protein, LOC506364 Protein
- Sujet
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Background: Siglec-8 is also known as SIGLEC8, SAF2, SIGLEC-8, SIGLEC8L and sialic acid binding Ig like lectin 8, is an approximately 75 kDa transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Siglec-8 is expressed on eosinophils, basophils, and mast cells, and it shows a binding preference for the carbohydrate 6-O sulfated sLex. At the tissue level, Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney. Mature human Siglec-8 consists of a 347 amino acid (aa) extracellular domain (ECD) with three Ig-like domains, a 21 aa transmembrane segment, and a 115 aa cytoplasmic domain with two tyrosine based signaling motifs. Alternative splicing generates additional isoforms that either lack most of the second Ig-like domain or have a substituted cytoplasmic domain without the signaling motifs. Cross-linking of Siglec-8 inhibits Fc epsilon RI alpha induced mast cell degranulation (9). It also induces eosinophil apoptosis, an effect which is enhanced by the eosinophil-activating cytokines IL-5, IL-33, and GM-CSF.
Synonym: Siglec8, Siglec-8, SAF2, SAF2SAF-2, SAF-2, CD329 antigen, CDw329
- Poids moléculaire
- 38.6 kDa
- UniProt
- Q9NYZ4
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