SIRPb2 Protein (Fc Tag)

N° du produit ABIN7319832

Détail du produit

Antigène: SIRPb2 (Signal-Regulatory Protein beta 2 (SIRPb2))

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette SIRPb2 protéine est marqué à la Fc Tag.

Fonction: Recombinant Human SIRPB2 (C-Fc)

Séquence: Gln33-Gly287

Attributs du produit: Recombinant Human Signal-regulatory Protein Beta-2 is produced by our Mammalian expression system and the target gene encoding Gln33-Gly287 is expressed with a Fc tag at the C-terminus.

Pureté: >95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: SIRPb2 (Signal-Regulatory Protein beta 2 (SIRPb2))

Autre désignation: SIRPB2 (SIRPb2 Produits)

Synonymes: PTPN1L Protein, PTPNS1L3 Protein, dJ776F14.2 Protein, SIRPG Protein, SIRPB2 Protein, signal regulatory protein beta 2 Protein, signal-regulatory protein beta-2 Protein, SIRPB2 Protein, LOC100146829 Protein

Sujet:

Background: Signal-regulatory protein beta-2(SIRP-beta-2), is a monomeric single pass type I membrane glycoprotein, belongs to the SIRP/SHPS (CD172) family of the immunoglobulin (Ig) superfamily. The SIRP family are paired receptors that have similar extracellular domains but differing C-terminal domains and functions. A positively charged residue within the transmembrane domain, in analogy to SIRP-beta-1, is implicated to mediate interaction with the adaptor DAP12 protein, which contains immunoreceptor tyrosine-based activation motifs (ITAMs) . Proteins in the SIRP family are typically expressed in immune cells, especially in the myeloid lineages . Based on expression patterns, SIRPs are thought to have roles in immune regulation. SIRP family members role in innate immunity and host defense has potential significance as a therapeutic target in cancer and inflammation. There are currently no known mouse or rat homologs for this protein.

Synonym: dJ776F14.2, PTPN1L, PTPNS1L3, Signal-Regulatory Protein Beta 2, Signal-Regulatory Protein Beta-2, SIRP beta 2, SIRP-beta-2, SIRPG

Poids moléculaire: 55.2 kDa

UniProt: Q5JXA9