SCN3B Protein (His tag)

N° du produit ABIN7317236

Détail du produit

Antigène: SCN3B (Sodium Channel, Voltage-Gated, Type III, beta Subunit (SCN3B))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette SCN3B protéine est marqué à la His tag.

Fonction: Recombinant Human SCN3B Protein (His Tag)

Séquence: Met 1-Glu159

Attributs du produit: A DNA sequence encoding the mature form of human SCN3B (Q9NY72) extracellular domain (Met1-Glu159) was expressed with a polyhistidine tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: SCN3B (Sodium Channel, Voltage-Gated, Type III, beta Subunit (SCN3B))

Autre désignation: SCN3B (SCN3B Produits)

Synonymes: 1110001K16Rik Protein, 4833414B02Rik Protein, Scnb3 Protein, HSA243396 Protein, SCNB3 Protein, sodium voltage-gated channel beta subunit 3 Protein, sodium channel, voltage-gated, type III, beta Protein, SCN3B Protein, Scn3b Protein

Sujet:

Background: SCN3B (sodium channel, voltage-gated, type III, beta ,human IgG1-Fc chimera) belongs to the sodium channel auxiliary subunit SCN3B family. It contains 1 Ig-like C2-type (immunoglobulin-like) domain. Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. SCN3B gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. Defects in SCN3B are the cause of Brugada syndrome type 7. A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram. It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.

Synonym: ATFB16,BRGDA7,HSA243396,SCNB3

Poids moléculaire: 17.2 kDa

UniProt: Q9NY72