TRF1 Protein (His tag)

N° du produit ABIN7317319

Détail du produit

Antigène: TRF1 (TERF1) (Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette TRF1 protéine est marqué à la His tag.

Fonction: Recombinant Human TERF1/TRF1 Protein (His Tag)

Séquence: Met 1-Asp 419

Attributs du produit: A DNA sequence encoding the human TERF1 isoform 2 (NP_003209.2) (Met 1-Asp 419) was expressed, with a polyhistidine tag at the N-terminus.

Pureté: > 90 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.0, 10 % glycerol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: TRF1 (TERF1) (Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1))

Autre désignation: TERF1/TRF1 (TERF1 Produits)

Synonymes: PIN2 Protein, TRBF1 Protein, TRF Protein, TRF1 Protein, hTRF1-AS Protein, t-TRF1 Protein, wu:fb74c04 Protein, TERF1 Protein, DKFZp459A0713 Protein, Pin2 Protein, Trbf1 Protein, Trf1 Protein, terf1 Protein, trf1 Protein, telomeric repeat binding factor 1 Protein, telomeric repeat binding factor (NIMA-interacting) 1 Protein, telomeric repeat binding factor (NIMA-interacting) 1 L homeolog Protein, TERF1 Protein, Terf1 Protein, terf1 Protein, Trf1 Protein, terf1.L Protein

Sujet:

Background: Telomeric repeat binding factor 1 (TRF1), also known as TERF1, the shelterin complex, which modulates the telomere structures. TRF1 protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Pin2/TRF1 was originally identified as a protein bound to telomeric DNA (TRF1) and as a protein involved in mitotic regulation (Pin2). Pin2/TRF1 negatively regulates telomere length and importantly, its function is tightly regulated during the cell cycle, acting as an important regulator of mitosis. TRF1 can be bound and modulated by two nucleolar GTP-binding proteins, nucleostemin (NS) and guanine nucleotide binding protein-like 3-like (GNL3L), which exhibit apparently opposite effects on the protein degradation of TRF1. TRF1/TERF1 may has association with cancer. TRF1 may play a significant role in cell differentiation in non-small cell lung cancer (NSCLC). The expression level of TRF1 protein is significantly reduced in kidney cancer and the level is negatively correlated with malignant degree of the cancer. TRF1 expression in malignant gliomas cells, may play a role in the malignant progression of astroglial brain tumors.

Synonym: FLJ41416,hTRF1-AS,PIN2,t-TRF1,TRBF1,TRF,TRF1

Poids moléculaire: 50.5 kDa

NCBI Accession: NP_003209

Pathways: Cycle Cellulaire, Telomere Maintenance, Hormone Transport, Chromatin Binding, Regulation of Cell Size, Positive Regulation of Endopeptidase Activity