THSD1 Protein (His tag)

N° du produit ABIN7320290

Détail du produit

Antigène: THSD1 (Thrombospondin, Type I, Domain Containing 1 (THSD1))

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette THSD1 protéine est marqué à la His tag.

Fonction: Recombinant Mouse THSD1/TMTSP Protein (His Tag)

Séquence: Met 1-Asn 412

Attributs du produit: A DNA sequence encoding the extracellular domain of mouse THSD1 (NP_062522.1) (Met 1-Asn 412) was expressed, with a C-terminal polyhistidine tag.

Pureté: > 95 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: THSD1 (Thrombospondin, Type I, Domain Containing 1 (THSD1))

Autre désignation: THSD1/TMTSP (THSD1 Produits)

Synonymes: 4833423O18Rik Protein, Tmtsp Protein, TMTSP Protein, UNQ3010 Protein, thrombospondin, type I, domain 1 Protein, thrombospondin type 1 domain containing 1 Protein, Thsd1 Protein, THSD1 Protein

Sujet:

Background: Thrombospondin type-1 domain-containing protein 1, also known as transmembrane molecule with thrombospondin module, THSD1 and TMTSP, is a single-pass type I membrane protein which contains one TSP type-1 domain. THSD1 is a multi-domain, multi-functional glycoprotein synthesized by many cells. Matricellular THSD1 modulates cell adhesion and proliferation. It is involved in angiogenesis, inflammation, wound healing and cancer. In vitro, nanomolar concentrations of Thrombospondin-1 are required to alter endothelial and vascular smooth muscle cell adhesion, proliferation, motility, and survival. As a major platelet protein, for a long time it was postulated to control hemostasis via platelet aggregate stabilization. THSD1 is a potent angiogenesis inhibitor, and down-regulation of THSD1 has been suggested to alter tumor growth by modulating angiogenesis in a variety of tumor types.

Synonym: 4833423O18Rik,Tmtsp

Poids moléculaire: 45 kDa

NCBI Accession: NP_062522