TMED1 Protein (Fc Tag)

N° du produit ABIN7319816

Cette protéine Recombinant TMED1 est exprimée dans Human Cells.

Aperçu rapide pour TMED1 Protein (Fc Tag) (ABIN7319816)

Antigène: TMED1 (Transmembrane Emp24 Protein Transport Domain Containing 1 (TMED1))

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Pureté: >90 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette TMED1 protéine est marqué à la Fc Tag.

Fonction: Recombinant Human TMED1 (C-Fc)

Séquence: Ala24-Asn194

Attributs du produit: Recombinant Human Transmembrane Emp24 Domain-containing Protein 1 is produced by our Mammalian expression system and the target gene encoding Ala24-Asn194 is expressed with a Fc tag at the C-terminus.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: TMED1 (Transmembrane Emp24 Protein Transport Domain Containing 1 (TMED1))

Autre désignation: TMED1

Sujet:

Background: TMED1 (Transmembrane Emp24 domain-containing protein 1) is a member of the TMED family of proteins (gene name TMED1). The TMED family of proteins are localized to membranes of the early secretory pathway, including the endoplasmic reticulum and Golgi, and function in vesicular protein trafficking. TMED1 is a 59 kDa monomer and has been reported to exist as homodimer. It contains 1 GOLD domain and is widely expressed. TMED1 is important in regulating innate immune signaling through its interaction with ST2L. Specifically, the GOLD domain in TMED1 interacts with the TIR domain of ST2L, a receptor for IL 33. This interaction promotes ST2L association with IL-33, allowing downstream signaling cascade activating MAP kinases, p38, and JNK. Studies have shown knockdown of TMED-1 in HUVECs impairs the IL-33 induced response resulting in reduction of IL-6 and IL-8 productions.

Synonym: IL1RL1-Binding Protein, Il1rl1l, IL1RL1LG, IL-1RL1LG, IL1RL1LGIL1RL1-binding protein, ST2L, T1/ST2 receptor binding protein, TMED1, Tp24

Poids moléculaire: 46.3 kDa

UniProt: Q13445