TMED1 Protein (His tag)

N° du produit ABIN7317262

Protéine Recombinant TMED1 exprimée dans HEK-293 Cells.

Aperçu rapide pour TMED1 Protein (His tag) (ABIN7317262)

Antigène: TMED1 (Transmembrane Emp24 Protein Transport Domain Containing 1 (TMED1))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293 Cells

Pureté: > 90 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette TMED1 protéine est marqué à la His tag.

Fonction: Recombinant Human TMED1 Protein (His Tag)(Active)

Séquence: Met 1-Asn194

Attributs du produit: A DNA sequence encoding the human TMED1 (Q13445) (Met1-Asn194) was expressed with a polyhistidine tag at the C-terminus.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Measured by its binding ability in a functional ELISA.2.Immobilized human TMED1-His at 10μg/mL (100μL/well) can bind human IL1R4-Fc, the EC50 of human IL1R4-Fc is 8-50ng/mL.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: TMED1 (Transmembrane Emp24 Protein Transport Domain Containing 1 (TMED1))

Autre désignation: TMED1

Sujet:

Background: TMED1 belongs to the EMP24/GP25L family. It contains 1 GOLD domain and is widely expressed. TMED1 binds to its receptor IL1RL1 and results in the activation of DNA binding by nuclear factor NF-kappa-B or transcription from the IL8 promoter and most likely requires other proteins to elicit these activities. Dendritic cells from Peyer's patches (but not from spleen) express TMED1 in response to treatment with LPS. TMED1 may play a role in vesicular protein trafficking, mainly in the early secretory pathway. It may act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side.

Synonym: Il1rl1l,IL1RL1LG,Tp24

Poids moléculaire: 20.6 kDa

UniProt: Q13445