TNFRSF4 Protein (His tag)

N° du produit ABIN7320702

Détail du produit

Antigène: TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Souris

Source: Human Cells

Purification/Conjugué: Cette TNFRSF4 protéine est marqué à la His tag.

Fonction: Recombinant Mouse OX40/TNFRSF4 Protein (His Tag)(Active)

Séquence: Val20-Pro211

Attributs du produit: Recombinant Mouse OX40L Receptor is produced by our Mammalian expression system and the target gene encoding Val20-Pro211 is expressed with a 6His tag at the C-terminus.

Pureté: > 95 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Immobilized Mouse OX40L-His(Cat: PKSM041119) at 0.8μg/ml(100 μl/well) can bind Biotinylated Mouse OX40-His. The ED50 of Mouse OX40-His is 23.17 ug/ml .

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))

Autre désignation: OX40/TNFRSF4 (TNFRSF4 Produits)

Synonymes: TNFRSF4 Protein, ACT35 Protein, CD134 Protein, Ly-70 Protein, Ox40 Protein, TXGP1L Protein, Txgp1 Protein, OX40 Protein, TNF receptor superfamily member 4 Protein, tumor necrosis factor receptor superfamily, member 4 Protein, TNFRSF4 Protein, Tnfrsf4 Protein

Sujet:

Background: OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.

Synonym: Tumor necrosis factor receptor superfamily member 4,Tnfrsf4,OX40,CD134,Txgp1

Poids moléculaire: 22.1 kDa

UniProt: P47741

Pathways: Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints