HLA DRA*01:01-DRB1*04:01 protein (V5 tag,SBP Tag,His tag)

N° du produit ABIN7273234

Détail du produit

Antigène: HLA DRA*01:01-DRB1*04:01

Type de proteíne: Recombinant

Origine: Humain

Source: Mammalian Cells

Purification/Conjugué: V5 tag,SBP Tag,His tag

Application: Blocking Peptide (BP), Control Peptide (CP), ELISA, Neutralization (Neut)

Fonction: The product is HLA DRA*01:01-DRB1*04:01 as zipper-stabilized heterodimer

Séquence: alpha chain: IKEEHVIIQA EFYLNPDQSG EFMFDFDGDE IFHVDMAKKE TVWRLEEFGR FASFEAQGAL ANIAVDKANL EIMTKRSNYT PITNVPPEVT VLTNSPVELR EPNVLICFID KFTPPVVNVT WLRNGKPVTT GVSETVFLPR EDHLFRKFHY LPFLPSTEDV YDCRVEHWGL DEPLLKHWEF DAPSPLPETT E
beta chain: GDTRPRFLEQ VKHECHFFNG TERVRFLDRY FYHQEEYVRF DSDVGEYRAV TELGRPDAEY WNSQKDLLEQ KRAAVDTYCR HNYGVGESFT VQRRVYPEVT VYPAKTQPLQ HHNLLVCSVN GFYPGSIEVR WFRNGQEEKT GVVSTGLIQN GDWTFQTLVM LETVPRSGEV YTCQVEHPSL TSPLTVEWRA RSESAQSK
Sequences without tags. Tag location is at the discretion of the manufacturer.

Specificité: HLA DRA*01:01-DRB1*04:01, P01903 / P01911
HLA-DRB1*04:01 is associated with different diseases such as multiple sclerosis, rheumatoid arthritis or type 1 diabetes mellitus. People bearing HLA-DRB1*04:01 are more likely to be asymptomatic during an infection with SARS-CoV-2.

Attributs du produit: HLAs are produced in mammalian cell cultures as recombinant, truncated, soluble antigens, as zipper-stabilized heterodimers (HLA class II). As part of our quality control, all HLA are analyzed for purity by gel electrophoresis, concentration is determined by ELISA (0.5 mg/ml) and their functionality is verified with a specific antiserum.

Purification: Chromatography

Pureté: > 80 %

niveau d'endotoxine: Endotoxins have not been removed

Information d'application

Indications d'application: ELISA: 10 - 1000 ng/mL

Commentaires:

sandwich ELISA, direct ELISA, bead ELISA, reactive with antibodies anti-V5 and anti-His and specific antiserum, B cell ELI Spot (predicted), in vitro memory B cell stimulation (predicted), HLA competition assay (predicted), control in various assays (predicted)

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Phosphate based buffer, pH 7.8, Sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 6 months

Détail du antigène

Antigène: HLA DRA*01:01-DRB1*04:01

Sujet: Human Leukozyte Antigen, human Antigen-presenting major histocompatibility complex class II (MHCII) molecule. Expressed on Antigen-presenting cells (APC), displays peptides to CD4-positive T cells. Involved in cellular immune response.

Poids moléculaire: approx. 65 - 70 kDa (approx. 30 kDa alpha chain and 35 - 39 kDa beta chain)

UniProt: P01903