beta-2 Microglobulin Protein (AA 21-119) (Fc Tag)

N° du produit ABIN7273890

Détail du produit

Antigène: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Type de proteíne: Recombinant

Attributs du protein: AA 21-119

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette beta-2 Microglobulin protéine est marqué à la Fc Tag.

Fonction: Mouse B2M/beta 2-Microglobulin Protein

Séquence: Ile21-Met119

Attributs du produit: Recombinant Mouse B2M/beta 2-Microglobulin Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Ile21-Met119.

Pureté: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Autre désignation: B2M (B2M Produits)

Synonymes: Ly-m11 Protein, beta2-m Protein, beta2m Protein, bwm Protein, wu:fa94c05 Protein, wu:fb10a09 Protein, b2m-W01 Protein, b2m-W03 Protein, b2m-Z01 Protein, b2m-Z02 Protein, b2m-Z03 Protein, B2M Protein, b2m Protein, B2MG Protein, wu:fb66f11 Protein, wu:fj01f08 Protein, zgc:64161 Protein, b-2-m Protein, beta-2-microglobulin Protein, beta-2 microglobulin Protein, beta-2-microglobulin S homeolog Protein, beta-2-microglobulin, like Protein, B2M Protein, B2m Protein, b2m Protein, b2m.S Protein, b2ml Protein

Sujet: The genetic and functional analysis of β2-microglobulin (B2M), a component of the HLA class-I complex.Acquired homozygous loss of B2M that caused lack of cell-surface HLA Class I expression in the tumor and a matched patient-derived xenograft (PDX). Downregulation of B2M was also found in two additional PDXs established from ICI-resistant tumors.

Poids moléculaire: 38.4 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.

UniProt: P01887

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process