ICOS Protein (AA 21-141) (Fc Tag)

N° du produit ABIN7274840

Détail du produit

Antigène: ICOS (Inducible T-Cell Co-Stimulator (ICOS))

Type de proteíne: Recombinant

Attributs du protein: AA 21-141

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette ICOS protéine est marqué à la Fc Tag.

Fonction: Human ICOS/CD278 (Q50A) Protein

Séquence: Glu21-Phe141

Attributs du produit: Recombinant Human ICOS/CD278 (Q50A) Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Glu21-Phe141.

Pureté: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Biological Activity Comment: The affinity constant of 25.59 nM as determined in SPR assay (Biacore T200). See testing image for detail.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: ICOS (Inducible T-Cell Co-Stimulator (ICOS))

Autre désignation: ICOS (ICOS Produits)

Synonymes: ICOS Protein, AILIM Protein, CCLP Protein, CRP-1 Protein, H4 Protein, Ly115 Protein, CD278 Protein, CVID1 Protein, Ailim Protein, inducible T-cell costimulator Protein, inducible T cell co-stimulator Protein, inducible T-cell co-stimulator Protein, ICOS Protein, LOC100232284 Protein, Icos Protein

Sujet: Inducible co-stimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) and CRP-1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. Human ICOS is a homodimeric type I transmembrane protein consisting of 199 amino acids (aa) with a putative 20 aa signal sequence, a 121 aa extracellular domain, a 23 aa transmembrane region, and a 35 aa cytoplasmic domain.

Poids moléculaire: 40.45 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Tris-Bis PAGE result.

Pathways: Cancer Immune Checkpoints