IL-13 Protein (AA 19-132) (His tag)

N° du produit ABIN7274876

Détail du produit

Antigène: IL-13 (IL13) (Interleukin 13 (IL13))

Type de proteíne: Recombinant

Attributs du protein: AA 19-132

Origine: Cynomolgus

Source: HEK-293 Cells

Purification/Conjugué: Cette IL-13 protéine est marqué à la His tag.

Fonction: Cynomolgus IL-13 Protein

Séquence: Ser19-Asn132

Attributs du produit: Recombinant Cynomolgus IL-13 Protein is expressed from HEK293 with His tag at the N-Terminus.It contains Ser19-Asn132.

Pureté: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Biological Activity Comment: The affinity constant of 21.16 nM as determined in SPR assay (Biacore T200). See testing image for detail.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: IL-13 (IL13) (Interleukin 13 (IL13))

Autre désignation: IL-13 (IL13 Produits)

Synonymes: IL13 Protein, IL-13 Protein, P600 Protein, Il-13 Protein, L13 Protein, interleukin 13 Protein, IL13 Protein, Il13 Protein

Sujet: Interleukin-13 (IL-13) is a monomeric 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.

Poids moléculaire: 13.59 kDa. Due to glycosylation, the protein migrates to 30-45 kDa based on Tris-Bis PAGE result.

UniProt: Q0PW92

Pathways: Signalistation JAK/STAT, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport