IL17C Protein (AA 19-197) (His-Avi Tag)

N° du produit ABIN7274998

Détail du produit

Antigène: IL17C (Interleukin 17C (IL17C))

Type de proteíne: Recombinant

Attributs du protein: AA 19-197

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette IL17C protéine est marqué à la His-Avi Tag.

Fonction: Human IL-17C Protein

Séquence: His19-Val197

Attributs du produit: Recombinant Human IL-17C Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains His19-Val197.

Pureté: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by SEC-HPLC

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Biological Activity Comment: Immobilized Human IL-17C at 5μg/ml (100μl/Well) on the plate. Dose response curve for Human IL-17R alpha, hFc Tag with the EC50 of 2.6μg/ml determined by ELISA. See testing image for detail.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in 50 mM MES, 150 mM NaCl (PH 6.0).

Buffer: Lyophilized from 0.22μm filtered solution in 50 mM MES, 150 mM NaCl (PH 6.0). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: IL17C (Interleukin 17C (IL17C))

Autre désignation: IL-17C (IL17C Produits)

Synonymes: IL17C Protein, il17-3 Protein, CX2 Protein, IL-17C Protein, IL-21 Protein, interleukin 17C Protein, interleukin 17c Protein, IL17C Protein, il17c Protein, Il17c Protein

Sujet: Interleukin-17C (IL-17C) is a 15-20 kDa glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. The six IL-17 cytokines (IL-17A-F) are encoded by separate genes but adopt a conserved cystine knot fold. IL-17C is Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G.

Poids moléculaire: 22.6 kDa. Due to glycosylation, the protein migrates to 25 kDa based on Tris-Bis PAGE result.

UniProt: Q9P0M4

Pathways: Cellular Response to Molecule of Bacterial Origin