IL21 Receptor Protein (AA 41-254) (His tag)
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- Antigène Voir toutes IL21 Receptor (IL21R) Protéines
- IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 41-254
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Origine
- Cynomolgus
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette IL21 Receptor protéine est marqué à la His tag.
- Fonction
- Cynomolgus IL-21R Protein
- Séquence
- Cys41-Gly254
- Attributs du produit
- Recombinant Cynomolgus IL-21R Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Cys41-Gly254.
- Pureté
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Stérilité
- 0.22 μm filtered
- niveau d'endotoxine
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Human IL-21 at 2μg/ml (100μl/well) on the plate. Dose response curve for Cynomolgus IL-21R, His Tag with the EC50 of 20.3ng/ml determined by ELISA. See testing image for detail.
- Top Product
- Discover our top product IL21R Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))
- Autre désignation
- IL-21R (IL21R Produits)
- Synonymes
- IL21R Protein, il-21ra.a Protein, CD360 Protein, NILR Protein, interleukin 21 receptor Protein, interleukin 21 receptor, tandem duplicate 1 Protein, IL21R Protein, il21r.1 Protein, Il21r Protein
- Sujet
- IL-21 and IL-21R were highly expressed in the lesional skin and peripheral blood of psoriasis patients. IL-21 promoted CD4 T cells proliferation and Th17 cells differentiation and inhibiting Treg cells differentiation by upregulating RORγt expression and downregulating Foxp3 expression, with increased expression and secretion of IL-17A and IL-22.Microbial translocation and the associated immune activation during HIV-1 infection may lead to high expression levels of the IL-21R activation marker in RM B cells, a feature associated with increased apoptosis and a reduced number of these cells in the circulation.
- Poids moléculaire
- 25.70 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.
- UniProt
- G7Q0S8
- Pathways
- Signalistation JAK/STAT
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