TMEM106B Protein (AA 119-275) (Fc Tag)

N° du produit ABIN7275691

Détail du produit

Antigène: TMEM106B (Transmembrane Protein 106B (TMEM106B))

Type de proteíne: Recombinant

Attributs du protein: AA 119-275

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette TMEM106B protéine est marqué à la Fc Tag.

Fonction: Mouse TMEM106B Protein

Séquence: Pro119-Gln275

Attributs du produit: Recombinant Mouse TMEM106B Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Pro119-Gln275.

Pureté: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: TMEM106B (Transmembrane Protein 106B (TMEM106B))

Autre désignation: TMEM106B (TMEM106B Produits)

Synonymes: 2310036D22Rik Protein, 5830455K21Rik Protein, 6430519M21Rik Protein, AI428776 Protein, AI661344 Protein, LRRGT00101 Protein, MGC81788 Protein, tmem106b Protein, zgc:114147 Protein, zgc:64013 Protein, transmembrane protein 106B Protein, transmembrane protein 106B S homeolog Protein, transmembrane protein 106Bb Protein, transmembrane protein 106b Protein, transmembrane protein 106Ba Protein, TMEM106B Protein, Tmem106b Protein, tmem106b.S Protein, tmem106b Protein, tmem106bb Protein, Tsp_02056 Protein, Tsp_01553 Protein, t106b Protein, tmem106ba Protein

Sujet: TMEM106B is a well-recognised risk factor for FTD caused by GRN mutation. Elegant experiments have suggested that increased risk for FTD is due to elevated levels of TMEM106B (Nicholson et al, 2013, Gallagher et al, 2017). Therefore, recent work has explored the therapeutic potential of reducing TMEM106B levels, with initial results looking encouraging, as crossing a Grn-deficient mouse to a Tmem106b knockout showed a rescue in FTD-related behavioural defects and specific aspects of lysosome dysfunction (Klein et al, 2017).

Poids moléculaire: 44.8 kDa. Due to glycosylation, the protein migrates to 65-68 kDa based on Tris-Bis PAGE result.

UniProt: Q80X71