Thyroperoxidase Protein (AA 32-834) (His tag)

N° du produit ABIN7275772

Détail du produit

Antigène: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Type de proteíne: Recombinant

Attributs du protein: AA 32-834

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette Thyroperoxidase protéine est marqué à la His tag.

Fonction: Mouse Thyroid Peroxidase Protein

Séquence: Gly32-Arg834

Attributs du produit: Recombinant Mouse Thyroid Peroxidase Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gly32-Arg834.

Pureté: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Autre désignation: Thyroid Peroxidase (TPO Produits)

Synonymes: MSA Protein, TDH2A Protein, TPX Protein, TPO Protein, msa Protein, tpx Protein, xtpo Protein, LOC100218312 Protein, thyroid peroxidase Protein, TPO Protein, Tpo Protein, tpo Protein, LOC100547103 Protein

Sujet: Thyroid peroxidase, also called thyroperoxidase (TPO) or iodide peroxidase that encodes a 933 amino-acid residue (aa) molecule with a single membrane-spanning region. Thyroid peroxidase plays a key role in thyroid hormone synthesis by catalyzing both the iodination of tyrosine residues to form monoiodotyrosine (MIT) and diiodotyrosine (DIT) residues and the coupling of iodotyrosine residues in Tg, resulting in the formation of T3 and T4. It is a frequent epitope of autoantibodies in autoimmune thyroid disease, for example, the expression of thyroid peroxidase is lost in papillary thyroid carcinoma.

Poids moléculaire: 90.6 kDa. Due to glycosylation, the protein migrates to 100-115 kDa based on Tris-Bis PAGE result.

UniProt: P35419

Pathways: Thyroid Hormone Synthesis