IL18BP Protein (AA 28-207) (His tag)

N° du produit ABIN7454151

Détail du produit

Antigène: IL18BP (Interleukin 18 Binding Protein (IL18BP))

Type de proteíne: Recombinant

Attributs du protein: AA 28-207

Origine: Cynomolgus

Source: HEK-293 Cells

Purification/Conjugué: Cette IL18BP protéine est marqué à la His tag.

Fonction: Cynomolgus IL-18BP Protein

Séquence: Thr28-Pro207

Attributs du produit: Recombinant Cynomolgus IL-18BP Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Thr28-Pro207.

Pureté: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Biological Activity Comment: Immobilized Human IL-18, No Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Cynomolgus IL-18BP, His Tag with the EC50 of 3.2ng/ml determined by ELISA. See testing image for detail.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: IL18BP (Interleukin 18 Binding Protein (IL18BP))

Autre désignation: IL-18BP (IL18BP Produits)

Synonymes: IL18BP Protein, IL-18BP Protein, Igifbp Protein, MC54L Protein, IL18BPa Protein, interleukin 18 binding protein Protein, IL18BP Protein, Il18bp Protein

Sujet: Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice.

Poids moléculaire: 21.14 kDa. Due to glycosylation, the protein migrates to 35-65 kDa based on Tris-Bis PAGE result.

UniProt: A0A2K5UDJ4