HLA-A*11:01 (Monomer) protein (Biotin,LMP2)

N° du produit ABIN7454312

Détail du produit

Antigène: HLA-A*11:01

Type de proteíne: Recombinant

Attributs du protein: Monomer

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Biotin,LMP2

Fonction: Biotinylated Human HLA-A*11:01 & B2M & LMP2 (SSCSSCPLTK) Monomer Protein

Séquence: Gly25-Thr305 (HLA-A*11:01), Ile21-Met119 (B2M) and SSCSSCPLTK peptide

Specificité: Uni-Prot: AAV53343.1 (HLA-A*11:01), P61769 (B2M), SSCSSCPLTK

Attributs du produit: Recombinant Biotinylated Human LMP2(HLA-A*11:01) Protein is expressed from HEK293 with with His tag and Avi tag at the C-Terminus.It contains Gly25-Thr305(HLA-A*11:01),Ile21-Met119(B2M) and SSCSSCPLTK peptide.

Pureté: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in 20 mM PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: HLA-A*11:01

Sujet: The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of malignant tumors that highly express LMP2.

Poids moléculaire: 50.4 kDa. Due to glycosylation, the protein migrates to 51-60 kDa based on Tris-Bis PAGE result.