SCUBE2 Protein (AA 441-659) (Fc Tag)

N° du produit ABIN7490771

Détail du produit

Antigène: SCUBE2 (Signal Peptide, CUB Domain, EGF-Like 2 (SCUBE2))

Type de proteíne: Recombinant

Attributs du protein: AA 441-659

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette SCUBE2 protéine est marqué à la Fc Tag.

Fonction: Recombinant human SCUBE2 (441-659) protein with C-terminal human Fc tag

Specificité: SCUBE2 (Asp441-Asn659 ) hFc (Glu99-Ala330)

Attributs du produit: Extracellular Domain Protein

Pureté: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: SCUBE2 (Signal Peptide, CUB Domain, EGF-Like 2 (SCUBE2))

Autre désignation: SCUBE2 (SCUBE2 Produits)

Synonymes: CEGB1 Protein, CEGF1 Protein, CEGP1 Protein, 4932442O19Rik Protein, Cegf1 Protein, Cegp1 Protein, RGD1563998 Protein, Scube2-ps1 Protein, wu:fc27f08 Protein, you Protein, signal peptide, CUB domain and EGF like domain containing 2 Protein, signal peptide, CUB domain, EGF-like 2 Protein, SCUBE2 Protein, Scube2 Protein, scube2 Protein

Sujet: CEGP1, Scube/YouLipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane (PubMed:22902404, PubMed:22677548). Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface (PubMed:24522195). Synergizes with DISP1 to increase SHH secretion (PubMed:22902404). Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed:27834687).[UniProtKB/Swiss-Prot Function]

Poids moléculaire: predicted molecular mass of 50.2 kDa after removal of the signal peptide. The apparent molecular mass of SCUBE2(441-659)-hFc is 35-55 kDa due to glycosylation.

UniProt: Q9NQ36